INT167593

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 14
Disease Relevance 3.07
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ly6a) intracellular (Ly6a)
Anatomy Link Frequency
stem cell 5
colon 2
brain 2
heart 2
kidney 2
Ly6a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 3 88.08 High High
Calcium channel 19 84.92 Quite High
Nerve growth factor 37 81.36 Quite High
Inflammation 37 80.64 Quite High
cerebral cortex 9 77.52 Quite High
spinal inflammation 2 74.60 Quite High
psoriasis 2 73.52 Quite High
antagonist 39 5.00 Very Low Very Low Very Low
cytokine 31 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 10 91.08 High High
INFLAMMATION 36 87.72 High High
Apoptosis 48 79.88 Quite High
Neurodegenerative Disease 12 75.20 Quite High
Low Back Pain 2 74.60 Quite High
Psoriasis 2 73.52 Quite High
Obesity 13 73.36 Quite High
Inflammatory Bowel Disease 4 73.08 Quite High
Cancer 26 69.76 Quite High
Death 10 58.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, ethanol induced asymmetric division in progenitor cells and decreased the cell surface expression of a number of stem cell markers, i.e., c-kit/CD117, Sca-1 (Ly6A/E), CD133/prominin-1 and the ABCG2 transporter.
Gene_expression (expression) of Ly6A/E in stem cell
1) Confidence 0.75 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.47 Pain Relevance 0.08
In the initial set of experiments, we utilized flow-cytometry to examine the expression of three stem cell markers, Sca-1 (Ly6A/E), CD117/c-kit and CD133/prominin-1.
Spec (examine) Gene_expression (expression) of Ly6A/E in stem cell
2) Confidence 0.75 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
We also analyzed the expression of the common stem cell markers Sca-1, p74NTR, ?
Spec (analyzed) Gene_expression (expression) of Sca-1 in stem cell
3) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0 Pain Relevance 0
Stem cell antigen 1 (Sca-1) is a cell-surface marker for murine hematopoietic stem cells [11,12] and is also expressed in some differentiated cell types, including cells of the heart, kidney, and brain [13].
Gene_expression (expressed) of Sca-1 in heart
4) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0.13 Pain Relevance 0.08
This was particularly true for Sca-1 (a cell surface marker for murine hematopoietic stem cells), which was expressed at 26-fold higher levels in SP cells than in non-SP cells (Figure 6).


Gene_expression (expressed) of Sca-1 in hematopoietic stem cells
5) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0 Pain Relevance 0
Stem cell antigen 1 (Sca-1) is a cell-surface marker for murine hematopoietic stem cells [11,12] and is also expressed in some differentiated cell types, including cells of the heart, kidney, and brain [13].
Gene_expression (expressed) of Stem cell antigen 1 in heart
6) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0.13 Pain Relevance 0.08
Stimulation of colonic leukocytes with IL-23 induced the production of IL-17 and interferon-gamma exclusively by innate lymphoid cells expressing Thy1, stem cell antigen 1 (SCA-1), retinoic-acid-related orphan receptor (ROR)-gammat and IL-23R, and these cells markedly accumulated in the inflamed colon.
Gene_expression (expressing) of stem cell antigen 1 in colon
7) Confidence 0.35 Published 2010 Journal Nature Section Abstract Doc Link 20393462 Disease Relevance 0.92 Pain Relevance 0.30
Stimulation of colonic leukocytes with IL-23 induced the production of IL-17 and interferon-gamma exclusively by innate lymphoid cells expressing Thy1, stem cell antigen 1 (SCA-1), retinoic-acid-related orphan receptor (ROR)-gammat and IL-23R, and these cells markedly accumulated in the inflamed colon.
Gene_expression (expressing) of SCA-1 in colon
8) Confidence 0.35 Published 2010 Journal Nature Section Abstract Doc Link 20393462 Disease Relevance 0.92 Pain Relevance 0.30
Furthermore, stem cell markers that are present in stem cells from other tissues, such as Sca-1, p75NTR, and Nes, were highly expressed in lens epithelial SP cells.
Gene_expression (expressed) of Sca-1 in stem cells
9) Confidence 0.21 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0 Pain Relevance 0.04
Stem cell antigen 1 (Sca-1) is a cell-surface marker for murine hematopoietic stem cells [11,12] and is also expressed in some differentiated cell types, including cells of the heart, kidney, and brain [13].
Gene_expression (expressed) of Stem cell antigen 1 in brain
10) Confidence 0.16 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0.13 Pain Relevance 0.08
Stem cell antigen 1 (Sca-1) is a cell-surface marker for murine hematopoietic stem cells [11,12] and is also expressed in some differentiated cell types, including cells of the heart, kidney, and brain [13].
Gene_expression (expressed) of Sca-1 in kidney
11) Confidence 0.16 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0.13 Pain Relevance 0.08
Stem cell antigen 1 (Sca-1) is a cell-surface marker for murine hematopoietic stem cells [11,12] and is also expressed in some differentiated cell types, including cells of the heart, kidney, and brain [13].
Gene_expression (expressed) of Sca-1 in brain
12) Confidence 0.16 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0.13 Pain Relevance 0.08
Stem cell antigen 1 (Sca-1) is a cell-surface marker for murine hematopoietic stem cells [11,12] and is also expressed in some differentiated cell types, including cells of the heart, kidney, and brain [13].
Gene_expression (expressed) of Stem cell antigen 1 in kidney
13) Confidence 0.16 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2890558 Disease Relevance 0.13 Pain Relevance 0.08
The SP cells include nestin-positive cells (656) and cells expressing stem cell antigen-1 (sca-1) and markers typical for stem cells in other tissues (Oct-4 and nanog) and early embryonic markers such as Lhx4 and molecules belonging to the Notch, Sonic hedgehog and Wnt signalling pathways (657).
Gene_expression (expressing) of stem cell antigen-1 in stem cell
14) Confidence 0.07 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0

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