INT167607

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.97
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 10 100.00 Very High Very High Very High
cINOD 12 81.28 Quite High
antagonist 6 79.60 Quite High
Thalamus 10 74.08 Quite High
Spinal cord 10 72.72 Quite High
Neuronal excitability 4 68.60 Quite High
long-term potentiation 22 63.84 Quite High
amygdala 4 20.60 Low Low
agonist 4 11.96 Low Low
Inflammation 53 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 15 99.16 Very High Very High Very High
Toxicity 22 98.40 Very High Very High Very High
Apoptosis 34 93.84 High High
Alzheimer's Dementia 242 93.68 High High
Targeted Disruption 277 85.88 High High
Amyloid Plaque 70 83.92 Quite High
Congenital Anomalies 18 83.52 Quite High
Parkinson's Disease 7 81.76 Quite High
Disease 564 80.24 Quite High
INFLAMMATION 63 79.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, as the intracellular domain of APP, one important function of AICD is to facilitate the interaction of APP with various cytosolic factors that regulate APP's intracellular trafficking and/or signal transduction function.
Positive_regulation (facilitate) of APP Binding (interaction) of
1) Confidence 0.50 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.23 Pain Relevance 0
An increasing number of proteins that interact with APP or act as trafficking factors are being implicated in the regulation of A?
Positive_regulation (increasing) of APP Binding (interact) of
2) Confidence 0.50 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.13 Pain Relevance 0.06
Interestingly, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
Positive_regulation (-) of APP Binding (interaction) of
3) Confidence 0.44 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.08 Pain Relevance 0
A YAC containing the hAPP gene encoding APP harboring the Swedish mutation, the London mutation or a combination of the two increased the A?
Positive_regulation (encoding) of hAPP Binding (gene) of
4) Confidence 0.44 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.60 Pain Relevance 0.06
In vitro, BACE2 can cleave APP at the ?
Positive_regulation (cleave) of APP Binding (In vitro) of
5) Confidence 0.39 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.15 Pain Relevance 0.08
studies reported the association of mutant APP derivatives with
Positive_regulation (derivatives) of mutant APP Binding (association) of
6) Confidence 0.37 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559913 Disease Relevance 0.53 Pain Relevance 0.13
Functionally, LRP's rapid endocytosis facilitates APP endocytic trafficking and A?
Positive_regulation (facilitates) of APP Binding (trafficking) of
7) Confidence 0.35 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0.28 Pain Relevance 0
These data show directly that changes in PS1 conformation can be detected following various manipulations of PS1 itself, Pen2, Aph1, APP, and pharmacological agents known as ?
Positive_regulation (manipulations) of APP Binding (agents) of
8) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.15 Pain Relevance 0
Al has been reported to increase the level of Abeta, promote Abeta aggregation, and increase Abeta neurotoxicity.
Positive_regulation (promote) of Abeta Binding (aggregation) of associated with drug induced neurotoxicity and abeta
9) Confidence 0.10 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20395307 Disease Relevance 0.83 Pain Relevance 0.53

General Comments

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