INT167637

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 3.35
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf)
proteinaceous extracellular matrix (Vwf) molecular_function (Vwf) response to stress (Vwf)
Anatomy Link Frequency
platelet 4
Vwf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 100.00 Very High Very High Very High
Central nervous system 2 92.16 High High
abdominal pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Thrombotic Thrombocytopenic Purpura 10 99.26 Very High Very High Very High
Thrombotic Microangiopathies 10 98.28 Very High Very High Very High
Renal Failure 2 95.16 Very High Very High Very High
Hemolytic Uremic Syndrome 6 94.16 High High
Fever 4 91.08 High High
Syndrome 2 76.72 Quite High
Infection 2 75.92 Quite High
Cancer 14 75.00 Quite High
Malignant Neoplastic Disease 8 65.76 Quite High
Disease 2 64.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TTP is usually associated with a severe deficiency of ADAMTS13 [a metalloproteinase involved in the degradation of von Willebrand factor (vWF) multimers], causing excessive accumulation of ultra-large vWF multimers and platelet aggregation with organ failure.
Negative_regulation (deficiency) of Protein_catabolism (degradation) of vWF in platelet associated with metalloproteinase and thrombotic thrombocytopenic purpura
1) Confidence 0.08 Published 2010 Journal Cardiovasc Hematol Disord Drug Targets Section Abstract Doc Link 20397971 Disease Relevance 1.72 Pain Relevance 0.10
TTP is usually associated with a severe deficiency of ADAMTS13 [a metalloproteinase involved in the degradation of von Willebrand factor (vWF) multimers], causing excessive accumulation of ultra-large vWF multimers and platelet aggregation with organ failure.
Negative_regulation (deficiency) of Protein_catabolism (degradation) of vWF in platelet associated with metalloproteinase and thrombotic thrombocytopenic purpura
2) Confidence 0.08 Published 2010 Journal Cardiovasc Hematol Disord Drug Targets Section Abstract Doc Link 20397971 Disease Relevance 1.63 Pain Relevance 0.10

General Comments

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