INT167637

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 3.35 Pain Relevance 0.19

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf) proteinaceous extracellular matrix (Vwf) molecular_function (Vwf) response to stress (Vwf)

Anatomy Link Frequency platelet 4 Vwf (Rattus norvegicus)

Pain Link Frequency Relevance Heat metalloproteinase 2 100.00 Central nervous system 2 92.16 abdominal pain 2 25.00

Disease Link Frequency Relevance Heat Thrombotic Thrombocytopenic Purpura 10 99.26 Thrombotic Microangiopathies 10 98.28 Renal Failure 2 95.16 Hemolytic Uremic Syndrome 6 94.16 Fever 4 91.08 Syndrome 2 76.72 Infection 2 75.92 Cancer 14 75.00 Malignant Neoplastic Disease 8 65.76 Disease 2 64.96

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

TTP is usually associated with a severe deficiency of ADAMTS13 [a metalloproteinase involved in the degradation of von Willebrand factor (vWF) multimers], causing excessive accumulation of ultra-large vWF multimers and platelet aggregation with organ failure.

Negative_regulation (deficiency) of Protein_catabolism (degradation) of vWF in platelet associated with metalloproteinase and thrombotic thrombocytopenic purpura

1) Confidence 0.08 Published 2010 Journal Cardiovasc Hematol Disord Drug Targets Section Abstract Doc Link 20397971 Disease Relevance 1.72 Pain Relevance 0.10

TTP is usually associated with a severe deficiency of ADAMTS13 [a metalloproteinase involved in the degradation of von Willebrand factor (vWF) multimers], causing excessive accumulation of ultra-large vWF multimers and platelet aggregation with organ failure.

Negative_regulation (deficiency) of Protein_catabolism (degradation) of vWF in platelet associated with metalloproteinase and thrombotic thrombocytopenic purpura

2) Confidence 0.08 Published 2010 Journal Cardiovasc Hematol Disord Drug Targets Section Abstract Doc Link 20397971 Disease Relevance 1.63 Pain Relevance 0.10

General Comments

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