INT16764

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Context Info
Confidence 0.69
First Reported 1985
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 39
Total Number 41
Disease Relevance 6.29
Pain Relevance 21.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Qrfp) cellular_component (Qrfp)
Anatomy Link Frequency
striatum 8
brain 4
nucleus 4
nucleus accumbens 2
basal ganglia 2
Qrfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 236 100.00 Very High Very High Very High
Enkephalin 79 100.00 Very High Very High Very High
Dynorphin 26 100.00 Very High Very High Very High
Calcitonin gene-related peptide 4 100.00 Very High Very High Very High
dopamine receptor 5 99.90 Very High Very High Very High
agonist 31 99.78 Very High Very High Very High
Glutamate receptor 6 99.62 Very High Very High Very High
Dopamine 86 99.56 Very High Very High Very High
Central nervous system 11 99.24 Very High Very High Very High
substance P 58 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 38 99.82 Very High Very High Very High
Diabetes Mellitus 13 99.00 Very High Very High Very High
Colitis 60 98.84 Very High Very High Very High
Convulsion 10 98.44 Very High Very High Very High
Hypoxia 4 98.08 Very High Very High Very High
Pain 4 97.88 Very High Very High Very High
Hypothermia 4 97.60 Very High Very High Very High
Dyspepsia 2 97.60 Very High Very High Very High
Targeted Disruption 6 97.56 Very High Very High Very High
Nervous System Injury 4 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuronal receptor and neuropeptide mRNA expression are upregulated within the first two hours following OM colitis [53].
Transcription (expression) of neuropeptide in Neuronal associated with colitis and neuropeptide
1) Confidence 0.69 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.43 Pain Relevance 0.81
A high density of 26RFa binding sites was detected in regions of the CNS involved in the processing of pain, such as the dorsal horn of the spinal cord and the parafascicular thalamic nucleus.
Transcription (detected) of 26RFa in nucleus associated with pain, dorsal horn, central nervous system and spinal cord
2) Confidence 0.67 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17534937 Disease Relevance 0.10 Pain Relevance 0.57
Furthermore, we studied the contribution of the dopamine D2 and serotonin 5-HT2A antagonist components of risperidone in establishing its effects on neuropeptide mRNA levels in the striatum.
Transcription (levels) of neuropeptide in striatum associated with dopamine, antagonist, neuropeptide and serotonin
3) Confidence 0.34 Published 1998 Journal Synapse Section Abstract Doc Link 9517839 Disease Relevance 0 Pain Relevance 0.34
Furthermore, the results suggest that the effects of risperidone on neuropeptide mRNA levels are fully accounted for by its D2 antagonism and that no indication exists for a role of 5-HT2A receptor blockade in this action.
Transcription (levels) of neuropeptide associated with neuropeptide
4) Confidence 0.34 Published 1998 Journal Synapse Section Abstract Doc Link 9517839 Disease Relevance 0 Pain Relevance 0.32
Kappa opioid receptor stimulation decreases amphetamine-induced behavior and neuropeptide mRNA expression in the striatum.
Transcription (expression) of neuropeptide in striatum associated with neuropeptide and kappa opioid receptor
5) Confidence 0.31 Published 2001 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 11532335 Disease Relevance 0 Pain Relevance 0.59
This study investigated the site of action of these effects by administering scopolamine and oxotremorine directly into the striatum and assessing the expression of neuropeptide mRNAs with quantitative in situ hybridization.
Transcription (expression) of neuropeptide in striatum associated with neuropeptide
6) Confidence 0.27 Published 1997 Journal Brain Res. Section Abstract Doc Link 9067445 Disease Relevance 0 Pain Relevance 0.51
We questioned whether psychologically distinct stressors would cause different patterns of neuropeptide mRNA expression within the PVN.
Transcription (expression) of neuropeptide associated with neuropeptide
7) Confidence 0.27 Published 1999 Journal J. Neuroendocrinol. Section Abstract Doc Link 10048467 Disease Relevance 0.59 Pain Relevance 0.32
The effect of stressor controllability on stress-induced neuropeptide mRNA expression within the paraventricular nucleus of the hypothalamus.
Transcription (expression) of neuropeptide in nucleus associated with stress, neuropeptide and enkephalin
8) Confidence 0.27 Published 1999 Journal J. Neuroendocrinol. Section Title Doc Link 10048467 Disease Relevance 0.68 Pain Relevance 0.49
Metabotropic glutamate receptor agonist increases neuropeptide mRNA expression in rat striatum.
Transcription (expression) of neuropeptide in striatum associated with glutamate receptor, neuropeptide, agonist and enkephalin
9) Confidence 0.22 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9555048 Disease Relevance 0 Pain Relevance 0.60
In this study, the effects of acute injection of the selective mGluR agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) on behavior and striatal neuropeptide mRNA expression were evaluated in chronically-cannulated rats.
Transcription (expression) of neuropeptide associated with neuropeptide and agonist
10) Confidence 0.22 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555048 Disease Relevance 0 Pain Relevance 0.44
However, no neuropeptide Y, galanin and calcitonin gene-related peptide messenger RNA was detected in the injured side gracile nuclei by in situ hybridization.
Transcription (detected) of neuropeptide associated with gracile nuclei, neuropeptide and calcitonin gene-related peptide
11) Confidence 0.18 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430497 Disease Relevance 0.61 Pain Relevance 0.92
These studies demonstrate that neuropeptide mRNAs can be detected within specific cells in the brain and that the patterns of hybridization match the localization of the peptides visualized by immunohistochemistry.
Transcription (detected) of neuropeptide in brain associated with neuropeptide
12) Confidence 0.16 Published 1985 Journal Neuropeptides Section Abstract Doc Link 3841195 Disease Relevance 0 Pain Relevance 0.05
Our results demonstrate that the effect of a chronic haloperidol treatment on striatal dopamine receptors and neuropeptide mRNA levels is different to that of sulpiride, whereas it is similar on pituitary hormones mRNA levels.
Transcription (levels) of neuropeptide in pituitary associated with dopamine receptor and neuropeptide
13) Confidence 0.14 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7518029 Disease Relevance 0 Pain Relevance 0.36
Effect of repeated administration of dopamine agonists on striatal neuropeptide mRNA expression in rats with a unilateral nigral 6-hydroxydopamine lesion.
Transcription (expression) of neuropeptide associated with dopamine, neuropeptide, agonist and enkephalin
14) Confidence 0.13 Published 1996 Journal J Neural Transm Section Title Doc Link 8739837 Disease Relevance 0 Pain Relevance 0.61
Expression of c-fos, tyrosine hydroxylase, and neuropeptide mRNA in the rat brain around birth: effects of hypoxia and hypothermia.
Transcription (Expression) of neuropeptide in brain associated with hypothermia, hypoxia, neuropeptide and enkephalin
15) Confidence 0.12 Published 1995 Journal Pediatr. Res. Section Title Doc Link 7700728 Disease Relevance 0.64 Pain Relevance 0.42
Effect of reserpine and colchicine on neuropeptide mRNA levels in the rat hypothalamic paraventricular nucleus.
Transcription (levels) of neuropeptide in nucleus associated with neuropeptide
16) Confidence 0.12 Published 1991 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 1850078 Disease Relevance 0 Pain Relevance 0.43
In all forebrain regions examined, with the exception of the islands of Calleja, the cellular expression of enkephalin messenger RNA and substance P messenger RNA was discordant; the two neuropeptide messenger RNAs were detected essentially in different cells, although in the striatum and nucleus accumbens occasional isolated cells were detected which contained both hybridization signals; dense clusters of silver grains overlay alkaline phosphatase-positive cells, demonstrating clearly that these dual-labelled cells expressed both messenger RNAs.
Transcription (detected) of neuropeptide in striatum associated with nucleus accumbens, neuropeptide, enkephalin and substance p
17) Confidence 0.12 Published 1997 Journal Neuroscience Section Abstract Doc Link 9135049 Disease Relevance 0 Pain Relevance 0.90
We conclude that exogenously applied BDNF increases neuropeptide mRNA expression in striatal neurones independently of the presence of a dopaminergic innervation.
Transcription (expression) of neuropeptide associated with neuropeptide
18) Confidence 0.11 Published 1994 Journal Neuroreport Section Abstract Doc Link 8025254 Disease Relevance 0 Pain Relevance 0.20
In a previous study, we have shown in unilaterally dopamine-depleted rats that increased behavioral responsiveness to the dopamine D1-receptor agonist SKF-38393, which was induced by pretreatment with L-DOPA, is paralleled by specific alterations in striatal neuropeptide mRNA levels.
Transcription (levels) of neuropeptide associated with dopamine, neuropeptide and agonist
19) Confidence 0.10 Published 2002 Journal Synapse Section Abstract Doc Link 11746728 Disease Relevance 0 Pain Relevance 0.39
MK-801 alters the effects of priming with L-DOPA on dopamine D1 receptor-induced changes in neuropeptide mRNA levels in the rat striatal output neurons.
Transcription (levels) of neuropeptide in output neurons associated with dopamine, neuropeptide and enkephalin
20) Confidence 0.10 Published 2002 Journal Synapse Section Title Doc Link 11746728 Disease Relevance 0 Pain Relevance 0.68

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