INT167650

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.14
Pain Relevance 1.00

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nucleolus (Ep300) nucleus (Ep300) transferase activity, transferring acyl groups (Ep300)
DNA binding (Ep300) transcription factor binding (Ep300) cytoplasm (Ep300)
Anatomy Link Frequency
neuronal 2
Ep300 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 8 97.84 Very High Very High Very High
Nerve growth factor 16 96.00 Very High Very High Very High
Pain 2 92.20 High High
Disease Link Frequency Relevance Heat
Pain 2 92.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dynamic association of p300 with the promoter of the G protein-coupled rat delta opioid receptor gene during NGF-induced neuronal differentiation.
p300 Binding (association) of in neuronal associated with opioid receptor
1) Confidence 0.09 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 20399742 Disease Relevance 0.09 Pain Relevance 0.53
Taken together, these results implicate that preassembly of the Pol II preinitiation complex, sustained activation of PI3K/Akt/NF-kappaB signaling, and dynamic p300 association at the promoters sequentially is one of the mechanisms of induction of the late phase genes during NGF-induced neuronal differentiation.
p300 Binding (association) of in neuronal associated with nerve growth factor
2) Confidence 0.09 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20399742 Disease Relevance 0.05 Pain Relevance 0.47

General Comments

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