INT167657

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Context Info
Confidence 0.75
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.48
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1) cell morphogenesis (Hmgb1) nucleolus (Hmgb1)
chromosome (Hmgb1) nucleus (Hmgb1) transcription factor binding (Hmgb1)
Anatomy Link Frequency
spinal 1
immune system 1
Hmgb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 44 100.00 Very High Very High Very High
Inflammation 41 100.00 Very High Very High Very High
spinal dorsal horn 3 99.16 Very High Very High Very High
Cancer pain 4 97.48 Very High Very High Very High
Inflammatory response 22 92.96 High High
cva 35 92.36 High High
Pain 6 88.68 High High
rheumatoid arthritis 31 80.88 Quite High
agonist 5 78.40 Quite High
allodynia 4 75.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 64 100.00 Very High Very High Very High
Cancer 6 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Bone Cancer 5 97.68 Very High Very High Very High
Disease 22 95.28 Very High Very High Very High
Hemorrhage 36 92.36 High High
Sepsis 64 91.80 High High
Cv General 2 Under Development 16 91.40 High High
Death 14 89.44 High High
Pain 4 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that HMGB1 could trigger the release of cytokines in the spinal dorsal horn and contribute to bone cancer pain.
Localization (release) of HMGB1 in spinal associated with cancer pain, spinal dorsal horn, bone cancer and cytokine
1) Confidence 0.75 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20399746 Disease Relevance 0.94 Pain Relevance 0.70
For example, excess amounts of bacteria toxins absorbed from the GI mucosa may directly stimulate the release of pro-inflammatory cytokines such as tumour necrosis factor (TNF), interleukin-1 (IL-1) [26], and high mobility group box-1 (HMGB1) protein [27], which could exacerbate inflammatory reactions [23,28,29], but also systemically affect the host's immune system for prolonged periods as non-specific immunostimulants.
Localization (release) of high mobility group box-1 in immune system associated with necrosis, inflammation, cancer and cytokine
2) Confidence 0.16 Published 2011 Journal Nutr J Section Body Doc Link PMC3022554 Disease Relevance 0.75 Pain Relevance 0.24
Proinflammatory cytokines such as tumor necrosis factor (TNF) or high-mobility group box1 (HMGB1) are fanatically released and cause lethal multiorgan dysfunction.
Localization (released) of high-mobility group box1 associated with necrosis, cancer and cytokine
3) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC2902015 Disease Relevance 1.78 Pain Relevance 0.73

General Comments

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