INT167677

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.61
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
osteoblast 1
T cells 1
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 3 99.34 Very High Very High Very High
chemokine 45 99.16 Very High Very High Very High
opiate 1 96.32 Very High Very High Very High
Inflammation 4 83.80 Quite High
Inflammatory mediators 1 53.32 Quite High
antagonist 22 5.00 Very Low Very Low Very Low
imagery 17 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Kinase C 8 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 405 99.98 Very High Very High Very High
Hypoxia 231 99.92 Very High Very High Very High
Infection 26 96.88 Very High Very High Very High
Metastasis 343 96.44 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 214 96.40 Very High Very High Very High
Osteoporosis 39 94.32 High High
Death 16 88.52 High High
Adhesions 35 87.04 High High
INFLAMMATION 7 83.80 Quite High
Apoptosis 69 81.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
signaling pathways regulate tumor-secreted factors such as CXCR4 which promotes tumor cell homing to the bone [50], and VEGF which stimulates tumor angiogenesis and increases both osteoclast [65], [69] and osteoblast activity [61].
Localization (secreted) of CXCR4 in osteoblast associated with cancer and osteoporosis
1) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.36 Pain Relevance 0
and hypoxia-regulated genes selected from Table 1: VEGF; CXCR4; PTHrP; IL-6, 8, 11; and CTGF.
Localization (selected) of CXCR4 associated with hypoxia
2) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.17 Pain Relevance 0
and hypoxia is localized within 300 base pairs in the VEGF promoter and in a 1.2 kb region for CXCR4.
Localization (localized) of CXCR4 associated with hypoxia
3) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.87 Pain Relevance 0
Tat and opiates have interactive effects on astroglial chemokine secretion, but this interaction did not occur in progenitors. gp120 did not affect chemokine/cytokine release, although both CCR5 and CXCR4, which serve as gp120 co-receptors, were detected in progenitors.
Localization (serve) of CXCR4 associated with chemokine, opiate and cytokine
4) Confidence 0.45 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20403075 Disease Relevance 0.65 Pain Relevance 0.57
Following internalization, CXCR4 colocalizes with Hrs-positive endosomes [20].
Localization (colocalizes) of CXCR4
5) Confidence 0.43 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.28 Pain Relevance 0
Previous studies have shown that T cells have large intracellular stores of CXCR4 that can be mobilized by treating the cells with PMA and ionomycin [17].
Localization (mobilized) of CXCR4 in T cells
6) Confidence 0.41 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 1.02 Pain Relevance 0
Similarly, it is possible that transient ligand exposure results in homologous receptor desensitization of both CXCR4 and CXCR7, while those receptors are more resilient to more sustained receptor activation.
Localization (desensitization) of CXCR4
7) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.69 Pain Relevance 0.13
Viruses that use the CCR5 or the CXCR4 coreceptors alone are called R5 or X4 viruses respectively, while those that can use both are referred to as R5X4 viruses.
Localization (use) of CXCR4
8) Confidence 0.33 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.57 Pain Relevance 0.05

General Comments

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