INT167679

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 74
Total Number 76
Disease Relevance 59.03
Pain Relevance 18.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) signal transduction (Ccr5) plasma membrane (Ccr5)
cell-cell signaling (Ccr5) cytoplasm (Ccr5) signal transducer activity (Ccr5)
Anatomy Link Frequency
brain 8
lymphocytes 6
T cells 6
macrophages 4
monocytes 3
Ccr5 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 3115 100.00 Very High Very High Very High
antagonist 294 100.00 Very High Very High Very High
Multiple sclerosis 1382 99.84 Very High Very High Very High
cytokine 690 99.52 Very High Very High Very High
Central nervous system 1152 98.18 Very High Very High Very High
Inflammation 1488 97.40 Very High Very High Very High
opiate 1 96.50 Very High Very High Very High
Inflammatory response 92 92.96 High High
rheumatoid arthritis 105 92.12 High High
Demyelination 276 76.96 Quite High
Disease Link Frequency Relevance Heat
Chlamydia Infection 960 100.00 Very High Very High Very High
Infection 1352 99.92 Very High Very High Very High
Demyelinating Disease 1796 99.84 Very High Very High Very High
Reprotox - General 3 42 99.64 Very High Very High Very High
Cerebral Malaria 858 99.60 Very High Very High Very High
Malaria 1056 99.54 Very High Very High Very High
Necrosis 139 99.40 Very High Very High Very High
Recurrence 374 99.26 Very High Very High Very High
Cancer 253 99.04 Very High Very High Very High
Reprotox - General 1 74 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of RANTES and its corresponding receptors, CCR1, CCR3 and CCR 5, were altered by P. yoelii 17XL infection and were significantly up-regulated (p < 0.002 for RANTES, p < 0.036 for CCR1, p < 0.033 for CCR3 and p < 0.026 for CCR5) in the brain during malaria infection.
Gene_expression (expression) of CCR 5 in brain associated with malaria and infection
1) Confidence 0.75 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.77 Pain Relevance 0.20
Moreover, increased expression of the CCR5 ligand, MIP-1a/CCL3, in humans (as a result of gene duplication) provides protection from HIV acquisition (Gonzalez et al 2005).
Gene_expression (expression) of CCR5 associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.73 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.54 Pain Relevance 0.20
mRNA expression during early stages of infection at inductive sites (i.e., spleen and ILN) preceded CCR5 expression at effectors sites (i.e., fallopian tube(s), uterus, and cervix).
Gene_expression (expression) of CCR5 in cervix associated with infection
3) Confidence 0.69 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.04 Pain Relevance 0.15
CCL5 is an important factor in the homing of lymphocytes that express CCR5, CCR4, CCR3 and CCR1 [31-33].
Gene_expression (express) of CCR5 in lymphocytes
4) Confidence 0.69 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.53 Pain Relevance 0.14
mRNA levels were elevated in inductive sites, while CCR5 mRNA expression was higher in the fallopian tubes than in the uterus and cervix.
Gene_expression (expression) of CCR5 mRNA in cervix
5) Confidence 0.69 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.74 Pain Relevance 0.16
These results corroborate our previous findings that CCR5-dependent mucosal immune responses are required for the efficient clearance of genital chlamydial infection, while functional CCR5 expression reduces infertility as a pathologic consequence of Th1-mediated inflammation associated with infection [22].
Gene_expression (expression) of CCR5 associated with reprotox - general 3, inflammation, chlamydia infection and infection
6) Confidence 0.69 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.79 Pain Relevance 0.16
Indeed, CCR5 mRNA expression by fallopian tube lymphocytes was significantly higher 7 and 14 days post infection.
Gene_expression (expression) of CCR5 mRNA in lymphocytes associated with infection
7) Confidence 0.69 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.16 Pain Relevance 0.14
Another key issue in the optimal administration of CCR5 antagonists, such as maraviroc, is which patient should receive these drugs: treatment-experienced or treatment-naïve patients?
Gene_expression (antagonists) of CCR5 associated with antagonist
8) Confidence 0.63 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.20 Pain Relevance 0.05
Besides maraviroc, several promising strategies for CCR5 blockade are currently being employed in the development of CCR5 antagonists.
Gene_expression (blockade) of CCR5 associated with antagonist
9) Confidence 0.63 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0 Pain Relevance 0.13
Moreover, both heterozygous as well as homozygous carriers of the CCR5 ?
Gene_expression (carriers) of CCR5
10) Confidence 0.63 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761192 Disease Relevance 0.67 Pain Relevance 0.07
RANTES binds to a variety of receptors including CCR1, CCR3 and CCR5, expressed by monocytes/macrophages, memory T-cells, eosinophils, endothelial cells, basophils and mast cells [11].
Gene_expression (expressed) of CCR5 in macrophages
11) Confidence 0.63 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.20 Pain Relevance 0.36
End othelial cells interacting with P. yoelii 17XL-parasitized erythrocytes have been shown to be induced to produce and present specific chemokines, such as RANTES, which can lure CCR1, CCR3 and CCR5 expressing cells into the brain [36].
Gene_expression (expressing) of CCR5 in brain associated with chemokine
12) Confidence 0.63 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.38 Pain Relevance 0.12
Recently, the up-regulated expression of RANTES and its receptors (C CR3 and CCR5) in the cerebellar and cerebral regions of post-mortem human CM brains has been reported [8].
Gene_expression (expression) of CCR5 in brains associated with cerebral malaria
13) Confidence 0.63 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.72 Pain Relevance 0.36
The expressions of all the C-C chemokine receptors for RANTES, CCR1, CCR3 and CCR5, were upregulated in the brains of P. yoelii 17XL-infected mice.
Gene_expression (expressions) of CCR5 in brains associated with chemokine
14) Confidence 0.63 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.50 Pain Relevance 0.40
Messenger RNA expression levels of CCR1, CCR3 and CCR5 were approximately two to three fold higher in infected mice than in controls [Figures 3B, 3C &3D].
Gene_expression (expression) of CCR5
15) Confidence 0.63 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.69 Pain Relevance 0.13
RANTES in addition to CCR1 and CCR5 are expressed by Th1 cells [30].
Gene_expression (expressed) of CCR5 in Th1 cells
16) Confidence 0.63 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.71 Pain Relevance 0.28
Tkachuk and colleagues observed that malaria infection induced the expression of CCR3 and CCR5 on placental macrophages in pregnant women [22].
Gene_expression (expression) of CCR5 in macrophages associated with malaria and infection
17) Confidence 0.63 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 1.60 Pain Relevance 0.20
CCR3 and CCR5 expression profiles were similar to the expression profile of their corresponding RANTES ligand.
Gene_expression (expression) of CCR5
18) Confidence 0.63 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.63 Pain Relevance 0.09
The expression of RANTES and CCR5 mRNA in P. yoelii 17XL-infected mouse brain in this study suggests a Th1-mediated immune response, and that factors capable of inducing Th1 response could play an important role in modulating malaria infections.
Gene_expression (expression) of CCR5 mRNA in brain associated with malaria and infection
19) Confidence 0.63 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.66 Pain Relevance 0.32
CCR5, but not CCL5 or IFN-?
Neg (not) Gene_expression (not) of CCR5
20) Confidence 0.60 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 1.19 Pain Relevance 0.11

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