INT16769

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1991
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 31
Total Number 36
Disease Relevance 8.29
Pain Relevance 29.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
medulla 4
DRG 4
spinal cord 3
plasma 2
gray matter 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 427 100.00 Very High Very High Very High
Opioid 210 100.00 Very High Very High Very High
mu opioid receptor 64 100.00 Very High Very High Very High
Pain 58 100.00 Very High Very High Very High
cocaine 35 100.00 Very High Very High Very High
Pyramidal cell 7 100.00 Very High Very High Very High
gABA 2 100.00 Very High Very High Very High
Morphine 258 99.98 Very High Very High Very High
agonist 89 99.98 Very High Very High Very High
Inflammation 83 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 11 100.00 Very High Very High Very High
INFLAMMATION 87 99.98 Very High Very High Very High
Respiratory Failure 5 99.98 Very High Very High Very High
Urological Neuroanatomy 53 99.44 Very High Very High Very High
Hyperalgesia 13 99.24 Very High Very High Very High
Convulsion 6 99.18 Very High Very High Very High
Opiate Addiction 4 98.08 Very High Very High Very High
Stress 25 98.00 Very High Very High Very High
Sleep Disorders 5 97.96 Very High Very High Very High
Sprains And Strains 7 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results support the hypothesis that the morphine-induced place preference is mainly mediated through the activation of the mu2-opioid receptor.
Positive_regulation (mediated) of Positive_regulation (activation) of mu2-opioid associated with opioid receptor and morphine
1) Confidence 0.57 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9430407 Disease Relevance 0.65 Pain Relevance 1.05
Antagonistic effect of buprenorphine on the antitussive effect of morphine is mediated via the activation of mu 1-opioid receptors.
Positive_regulation (mediated) of Positive_regulation (activation) of mu 1-opioid associated with qutenza, opioid receptor, morphine and buprenorphine
2) Confidence 0.47 Published 1995 Journal Life Sci. Section Title Doc Link 7564887 Disease Relevance 0.09 Pain Relevance 1.44
Increased level of neuronal phosphoinositide 3-kinase gamma by the activation of mu-opioid receptor in the mouse periaqueductal gray matter: further evidence for the implication in morphine-induced antinociception.
Positive_regulation (Increased) of Positive_regulation (activation) of mu-opioid receptor in gray matter associated with pain, antinociception, opioid receptor, central grey and morphine
3) Confidence 0.45 Published 2004 Journal Neuroscience Section Title Doc Link 14980723 Disease Relevance 0.38 Pain Relevance 1.01
These results suggest that genetic differences in MOP-r activation and DAT expression may be responsible for individual differences in vulnerability to heroin addiction.
Spec (may) Positive_regulation (responsible) of Positive_regulation (activation) of MOP-r associated with addiction and opiate addiction
4) Confidence 0.43 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20384817 Disease Relevance 0.44 Pain Relevance 0.32
Lack of mu-opioid receptor-mediated G-protein activation in the spinal cord of mice lacking Exon 1 or Exons 2 and 3 of the MOR-1 gene.
Positive_regulation (mediated) of Positive_regulation (activation) of mu-opioid receptor in spinal cord associated with opioid receptor and spinal cord
5) Confidence 0.42 Published 2003 Journal J. Pharmacol. Sci. Section Title Doc Link 14737012 Disease Relevance 0.15 Pain Relevance 1.00
Dopamine (DA) antagonists, SCH 23390, eticlopride, and nafadotride, blocked, and DA agonists, SKF 38393, R(+)-6-bromo-APB hydrobromide, and bromocriptine, mimicked the cocaine-induced upregulation of MOR mRNA, suggesting involvement of both subfamilies of DA receptors in the effect of cocaine.
Positive_regulation (cocaine-induced) of Positive_regulation (upregulation) of MOR mRNA associated with dopamine, antagonist, mu opioid receptor, agonist and cocaine
6) Confidence 0.42 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9673791 Disease Relevance 0 Pain Relevance 1.14
Therefore, activation of opioid mu-receptor by opioid from adrenal gland appears to be responsible for the plasma glucose lowering response to cold-stress in diabetic mice with insulin deficiency.
Spec (appears) Positive_regulation (responsible) of Positive_regulation (activation) of mu-receptor in plasma associated with stress, diabetes mellitus and opioid
7) Confidence 0.40 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11427305 Disease Relevance 1.23 Pain Relevance 0.74
Opioid agonists display different capacities to stimulate mu-opioid receptor (MOR) endocytosis, which is related to their ability to provoke the phosphorylation of specific cytosolic residues in the MORs.
Positive_regulation (provoke) of Positive_regulation (stimulate) of mu-opioid receptor associated with mu agonist and opioid receptor
8) Confidence 0.40 Published 2007 Journal Cell. Signal. Section Abstract Doc Link 17825524 Disease Relevance 0.20 Pain Relevance 0.80
Opioid agonists display different capacities to stimulate mu-opioid receptor (MOR) endocytosis, which is related to their ability to provoke the phosphorylation of specific cytosolic residues in the MORs.
Positive_regulation (provoke) of Positive_regulation (stimulate) of MOR associated with mu agonist and opioid receptor
9) Confidence 0.40 Published 2007 Journal Cell. Signal. Section Abstract Doc Link 17825524 Disease Relevance 0.20 Pain Relevance 0.80
The temporal characteristics of DA agonist induced increase in the levels of MOR mRNA in n. acc. were similar to those of cocaine, with maximum effect after 3 days of treatment.
Positive_regulation (induced) of Positive_regulation (increase) of MOR mRNA associated with dopamine, mu opioid receptor, agonist and cocaine
10) Confidence 0.39 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9673791 Disease Relevance 0 Pain Relevance 1.35
Morphine-induced MOR activation recruits PKC, primarily PKC?
Positive_regulation (induced) of Positive_regulation (activation) of MOR associated with kinase c, opioid receptor and morphine
11) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.07 Pain Relevance 0.93
Unilateral Freund's complete adjuvant inflammation of one hindpaw induced a significant up-regulation of MOP receptor sites only in DRG but not in HT or SC.
Positive_regulation (induced) of Positive_regulation (up-regulation) of MOP receptor in DRG associated with inflammation and spinal cord
12) Confidence 0.36 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14593084 Disease Relevance 0.59 Pain Relevance 1.02
These results suggest that repeated stimulation of kappa-opioid receptors leads to the heterologous up-regulation of mu-opioid receptor functions in the thalamus and periaqueductal gray regions, which may be associated with the supersensitivity of mu-opioid receptor-mediated antinociception.
Positive_regulation (leads) of Positive_regulation (up-regulation) of mu-opioid receptor in thalamus associated with antinociception, kappa opioid receptor, thalamus, opioid receptor and central grey
13) Confidence 0.34 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12753076 Disease Relevance 0.20 Pain Relevance 1.05
Furthermore, this may result in the increase of MOR activity and in the inhibition of morphine tolerance under chronic pain condition.


Positive_regulation (result) of Positive_regulation (increase) of MOR
14) Confidence 0.30 Published 2010 Journal J. Pharm. Pharmacol. Section Body Doc Link 20663033 Disease Relevance 0.05 Pain Relevance 0
Mu-opioid receptor activation induces transcriptional plasticity in the central extended amygdala.
Positive_regulation (induces) of Positive_regulation (activation) of Mu-opioid receptor in amygdala associated with opioid receptor and amygdala
15) Confidence 0.29 Published 2008 Journal Eur. J. Neurosci. Section Title Doc Link 18588537 Disease Relevance 0.13 Pain Relevance 0.60
The aim of the present study was to investigate whether mice with a deletion of the gene that encodes the protein kinase C gamma (PKC gamma) isoform could affect the G-protein activation mediated through the opioid receptor-like (ORL-1) receptor and mu-opioid receptor in the mouse pons/medulla and spinal cord, monitoring the guanosine-5'-o-(3-[(35)S]thio) triphosphate ([(35)S]GTP gamma S) binding assay.
Positive_regulation (mediated) of Positive_regulation (activation) of mu-opioid receptor in medulla associated with medulla, kinase c, opioid receptor and spinal cord
16) Confidence 0.26 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12359310 Disease Relevance 0.12 Pain Relevance 0.68
In Neuro2A MOR1A cells, acute, but not prolonged, morphine treatment elevated Arc mRNA level by activation of mu-opioid receptor.
Positive_regulation (elevated) of Positive_regulation (activation) of mu-opioid receptor associated with aids-related complex, opioid receptor and morphine
17) Confidence 0.25 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.90 Pain Relevance 1.31
The limited capacity of morphine to stimulate both Ser375 phosphorylation and MOR internalization could be due to its high off rate from the activated MOR.
Positive_regulation (due) of Positive_regulation (activated) of MOR associated with morphine
18) Confidence 0.24 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0.15 Pain Relevance 1.38
The functional role of CREB in the induction of MOR gene was further elucidated by an experiment in which a dominant-negative mutant CREB, CREB-S133A, abolished the forskolin-mediated MOR induction.
Positive_regulation (role) of Positive_regulation (induction) of MOR associated with opioid receptor
19) Confidence 0.18 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14645671 Disease Relevance 0.13 Pain Relevance 0.79
The hippocampal formation is a brain region sensitive to seizure development, a phenomenon thought to be mediated in part by mu-opioid receptor (MOR) activation.
Positive_regulation (mediated) of in brain Positive_regulation (activation) of MOR in hippocampal formation associated with convulsion and opioid receptor
20) Confidence 0.15 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 12618127 Disease Relevance 0.52 Pain Relevance 0.29

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox