INT167696

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.22
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NQO1) small molecule metabolic process (NQO1) oxidoreductase activity (NQO1)
cellular nitrogen compound metabolic process (NQO1) cytoplasm (NQO1)
Anatomy Link Frequency
hepatocytes 2
colon 2
NQO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 4 100.00 Very High Very High Very High
Glutamate 4 99.08 Very High Very High Very High
cINOD 5 48.48 Quite Low
Inflammation 65 12.56 Low Low
psoriasis 66 5.00 Very Low Very Low Very Low
cytokine 27 5.00 Very Low Very Low Very Low
chemokine 21 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 40 97.56 Very High Very High Very High
Stomach Cancer 2 94.04 High High
Targeted Disruption 4 94.00 High High
Injury 6 91.88 High High
Stress 44 75.00 Quite High
Hepatotoxicity 1 75.00 Quite High
Wound Healing 3 64.96 Quite High
INFLAMMATION 72 48.28 Quite Low
Cancer 15 39.44 Quite Low
Apoptosis 14 37.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, exposure of wild-type C57BL/6x129 Sv mice to nimesulide (100 mg/kg/day, po, for 5 days) was associated with nuclear translocation of immunoreactive Nrf2 in a small number of hepatocytes and induced >2-fold the expression levels of the Nrf2-target gene Nqo1 in wild-type but not Nrf2-null mice.
Positive_regulation (induced) of Gene_expression (expression) of Nqo1 in hepatocytes
1) Confidence 0.45 Published 2010 Journal Chem. Res. Toxicol. Section Abstract Doc Link 20405857 Disease Relevance 0.65 Pain Relevance 0
Isothiocyanates induced protein expression of AKR1C1, NAD(P)H:quinone oxidoreductase 1 (NQO1) and heavy subunit of glutamate-cysteine ligase (GCLC) in a colon cancer cell line [43].
Positive_regulation (induced) of Gene_expression (expression) of NQO1 in colon associated with glutamate and colon cancer
2) Confidence 0.21 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.19 Pain Relevance 0.05
The transcriptional response to these agents is typically mediated by the cis-acting antioxidant response element (ARE), found in the promoter of the encoding genes for diverse products such as several glutathione S-transferases, metalloproteinases, NADPH:quinone oxidoreductase 1, UDP glucuronotransferase, ?
Positive_regulation (transferases) of Gene_expression (transferases) of quinone oxidoreductase 1 associated with metalloproteinase
3) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.13 Pain Relevance 0.10
The transcriptional response to these agents is typically mediated by the cis-acting antioxidant response element (ARE), found in the promoter of the encoding genes for diverse products such as several glutathione S-transferases, metalloproteinases, NADPH:quinone oxidoreductase 1, UDP glucuronotransferase, ?
Positive_regulation (response) of Gene_expression (transferases) of quinone oxidoreductase 1 associated with metalloproteinase
4) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.13 Pain Relevance 0.10
The transcriptional response to these agents is typically mediated by the cis-acting antioxidant response element (ARE), found in the promoter of the encoding genes for diverse products such as several glutathione S-transferases, metalloproteinases, NADPH:quinone oxidoreductase 1, UDP glucuronotransferase, ?
Positive_regulation (cis-acting) of Gene_expression (transferases) of quinone oxidoreductase 1 associated with metalloproteinase
5) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.13 Pain Relevance 0.10

General Comments

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