INT167699

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.12
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1)
Anatomy Link Frequency
tail 2
Dio1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 80 100.00 Very High Very High Very High
dopamine receptor 4 100.00 Very High Very High Very High
depression 40 99.82 Very High Very High Very High
antidepressant 5 98.72 Very High Very High Very High
Neurotransmitter 6 96.80 Very High Very High Very High
antagonist 18 96.68 Very High Very High Very High
monoamine 8 95.52 Very High Very High Very High
Eae 7 95.52 Very High Very High Very High
Pyramidal cell 13 94.80 High High
agonist 13 92.60 High High
Disease Link Frequency Relevance Heat
Depression 40 99.82 Very High Very High Very High
Targeted Disruption 11 66.56 Quite High
Disease 6 58.32 Quite High
Aggression 1 52.56 Quite High
Affective Disorder 1 51.60 Quite High
Alcohol Addiction 1 49.92 Quite Low
Attention Deficit Hyperactivity Disorder 6 48.72 Quite Low
Schizophrenia 12 36.96 Quite Low
Pain 2 35.28 Quite Low
Dyskinesias 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that the antidepressant-like effect of melatonin in the tail suspension test is likely mediated by an interaction with the dopaminergic system, through an activation of dopamine D1 and D2 receptors.
Spec (likely) Positive_regulation (mediated) of Positive_regulation (activation) of D1 in tail associated with dopamine and antidepressant
1) Confidence 0.26 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20406627 Disease Relevance 0.09 Pain Relevance 1.02
For example, activation of both D1 and D2 dopamine receptors is necessary to induce movement in conditions of dopamine deficiency [12].


Positive_regulation (induce) of Positive_regulation (activation) of D1 associated with dopamine and dopamine receptor
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956650 Disease Relevance 0.23 Pain Relevance 0.26
In the PrPFC, eCB-LTD did not require the activation of NMDAR, D1 or D2 dopamine receptors, as demonstrated by the lack of effects of a cocktail of antagonist of these receptors (Fig 5A).
Neg (not) Positive_regulation (require) of Positive_regulation (activation) of D1 associated with depression, antagonist and dopamine receptor
3) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.80 Pain Relevance 0.75

General Comments

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