INT167705

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.32
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Clcn2) transmembrane transport (Clcn2)
Anatomy Link Frequency
CLC 1
Clcn2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 8 97.52 Very High Very High Very High
spastic colon 1 89.12 High High
Morphine 15 79.92 Quite High
addiction 2 56.48 Quite High
agonist 1 42.64 Quite Low
fibrosis 14 5.00 Very Low Very Low Very Low
Central nervous system 13 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 24 98.52 Very High Very High Very High
Apoptosis 169 96.48 Very High Very High Very High
Constipation 2 93.28 High High
Functional Bowel Disorder 1 89.12 High High
Hypopituitarism 2 85.28 High High
Epilepsy 2 82.32 Quite High
Convulsion 5 73.20 Quite High
Retina Disease 2 67.60 Quite High
Male Infertility 2 65.68 Quite High
Targeted Disruption 13 51.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of ClC-2 may help the ligandgated Cl?
Positive_regulation (Activation) of ClC-2
1) Confidence 0.46 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792346 Disease Relevance 0.55 Pain Relevance 0.09
Lubiprostone activates ClC-2 chloride channels in epithelia.
Positive_regulation (activates) of ClC-2
2) Confidence 0.43 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20406855 Disease Relevance 0.27 Pain Relevance 0.42
The ClC-2 channel is activated by hyperpolarization, acidic pH and swelling of the cell [31, 32].
Positive_regulation (activated) of ClC-2 associated with pressure and volume under development
3) Confidence 0.31 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792346 Disease Relevance 0.18 Pain Relevance 0.09
Activation of CLC-2 and CLC-3 channels are detected in cultured cortical neurons upon induction of AVD and apoptosis by staurosporine, C2-ceramide and serum deprivation respectively [136].
Positive_regulation (Activation) of CLC-2 in CLC associated with apoptosis
4) Confidence 0.06 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.31 Pain Relevance 0.03

General Comments

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