INT167712

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Jak1) cytoplasm (Jak1)
Anatomy Link Frequency
microglia 2
Jak1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 1 98.16 Very High Very High Very High
Spinal cord 6 95.84 Very High Very High Very High
Inflammation 1 92.12 High High
Peripheral nerve injury 3 85.64 High High
Neuropathic pain 2 84.44 Quite High
allodynia 3 75.00 Quite High
cytokine 2 72.00 Quite High
chemokine 1 53.04 Quite High
Eae 1 45.52 Quite Low
Sciatic nerve 3 42.72 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 97.80 Very High Very High Very High
Nervous System Injury 3 85.64 High High
Neuropathic Pain 5 84.44 Quite High
Injury 1 43.84 Quite Low
Hypersensitivity 1 37.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed recently that spinal nerve lesion leads to rapid activation of Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signal transduction pathway in dorsal spinal cord microglia in relation with enhanced levels of spinal interleukin-6 (IL-6) protein.
Positive_regulation (leads) of Positive_regulation (activation) of Janus kinase in microglia associated with spinal cord
1) Confidence 0.23 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20410127 Disease Relevance 0.57 Pain Relevance 0.63

General Comments

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