INT167716

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 6.64
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gnrhr) plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
neurons 2
Gnrhr (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 10 100.00 Very High Very High Very High
Somatostatin 10 99.98 Very High Very High Very High
tetrodotoxin 1 66.80 Quite High
antagonist 1 65.32 Quite High
agonist 1 45.72 Quite Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Dopamine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 60 100.00 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 20 100.00 Very High Very High Very High
Blepharophimosis 20 100.00 Very High Very High Very High
Premature Ovarian Failure 50 98.80 Very High Very High Very High
Repression 130 72.08 Quite High
Targeted Disruption 72 49.80 Quite Low
Adhesions 20 5.00 Very Low Very Low Very Low
Apoptosis 20 5.00 Very Low Very Low Very Low
Cancer 20 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Negative_regulation (blepharophimosis) of Gene_expression (cAMP) of GnRHR associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
1) Confidence 0.35 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.67 Pain Relevance 0.05
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Negative_regulation (/) of Gene_expression (cAMP) of GnRHR associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
2) Confidence 0.35 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.67 Pain Relevance 0.05
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Negative_regulation (monophophate) of Gene_expression (cAMP) of GnRHR associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
3) Confidence 0.35 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.64 Pain Relevance 0.05
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Negative_regulation (/) of Gene_expression (cAMP) of GnRHR associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
4) Confidence 0.35 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.67 Pain Relevance 0.05
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Negative_regulation (ptosis) of Gene_expression (cAMP) of GnRHR associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
5) Confidence 0.35 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.67 Pain Relevance 0.05
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Negative_regulation (/) of Gene_expression (cAMP) of gonadotropin releasing hormone receptor associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
6) Confidence 0.30 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.67 Pain Relevance 0.05
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Negative_regulation (blepharophimosis) of Gene_expression (cAMP) of gonadotropin releasing hormone receptor associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
7) Confidence 0.30 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.67 Pain Relevance 0.05
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Negative_regulation (/) of Gene_expression (cAMP) of gonadotropin releasing hormone receptor associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
8) Confidence 0.30 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.67 Pain Relevance 0.05
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Negative_regulation (ptosis) of Gene_expression (cAMP) of gonadotropin releasing hormone receptor associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
9) Confidence 0.30 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.67 Pain Relevance 0.05
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Negative_regulation (monophophate) of Gene_expression (cAMP) of gonadotropin releasing hormone receptor associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
10) Confidence 0.30 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.65 Pain Relevance 0.05
Somatostatin inhibition of gonadotropin-releasing hormone neurons in female and male mice.
Negative_regulation (inhibition) of Gene_expression (neurons) of gonadotropin-releasing hormone in neurons associated with somatostatin
11) Confidence 0.22 Published 2010 Journal Endocrinology Section Title Doc Link 20410192 Disease Relevance 0 Pain Relevance 0.43

General Comments

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