INT167717

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 2.49
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gnrhr) plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
neurons 2
granulosa cells 1
ovary 1
Gnrhr (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 4 100.00 Very High Very High Very High
Somatostatin 10 99.70 Very High Very High Very High
tetrodotoxin 2 99.22 Very High Very High Very High
Action potential 3 68.48 Quite High
antagonist 1 65.32 Quite High
Dopamine 4 51.20 Quite High
agonist 2 45.72 Quite Low
sodium channel 1 44.44 Quite Low
cva 1 14.64 Low Low
cytokine 4 6.12 Low Low
Disease Link Frequency Relevance Heat
Syndrome 24 98.08 Very High Very High Very High
Blepharophimosis 8 97.84 Very High Very High Very High
Aging 5 97.76 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 8 97.16 Very High Very High Very High
Premature Ovarian Failure 20 95.68 Very High Very High Very High
Endometriosis (extended) 11 92.40 High High
Apoptosis 9 86.80 High High
Cognitive Disorder 20 83.24 Quite High
Virilism 15 75.00 Quite High
Repression 52 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The human GnRH receptor has been shown to be expressed predominantly in granulosa cells of pre-ovulatory follicles [40].
Gene_expression (expressed) of GnRH receptor in granulosa cells
1) Confidence 0.55 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.15 Pain Relevance 0.03
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Gene_expression (cAMP) of GnRHR associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
2) Confidence 0.55 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.64 Pain Relevance 0.05
Estradiol attenuates multiple tetrodotoxin-sensitive sodium currents in isolated gonadotropin-releasing hormone neurons.
Gene_expression (neurons) of gonadotropin-releasing hormone in neurons associated with tetrodotoxin
3) Confidence 0.51 Published 2010 Journal Brain Res. Section Title Doc Link 20580637 Disease Relevance 0 Pain Relevance 0.13
The GnRHR gene was chosen for further study because it is known to be expressed in the ovary and the results of previous work has indicated that Foxl2 may regulate GnRHR gene expression.
Gene_expression (expression) of GnRHR in ovary
4) Confidence 0.49 Published 2010 Journal J Ovarian Res Section Abstract Doc Link PMC2831895 Disease Relevance 0 Pain Relevance 0
cAMP: cyclic adenosine monophophate; GnRHR: gonadotropin releasing hormone receptor; StAR: steroidogenic acute regulatory protein; BPES: blepharophimosis/ptosis/epicanthus inversus syndrome; POF: premature ovarian failure; LacZ: ?
Gene_expression (cAMP) of gonadotropin releasing hormone receptor associated with adenocard, syndrome, ocular toxicity (including many sub-types), premature ovarian failure and blepharophimosis
5) Confidence 0.48 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.65 Pain Relevance 0.05
Somatostatin inhibition of gonadotropin-releasing hormone neurons in female and male mice.
Gene_expression (neurons) of gonadotropin-releasing hormone in neurons associated with somatostatin
6) Confidence 0.35 Published 2010 Journal Endocrinology Section Title Doc Link 20410192 Disease Relevance 0 Pain Relevance 0.43
Testicular development is arrested in the hypogonadal (hpg) mouse due to a congenital deficiency in hypothalamic gonadotropin-releasing hormone (GnRH) synthesis.
Gene_expression (synthesis) of gonadotropin-releasing hormone
7) Confidence 0.34 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1249589 Disease Relevance 0.07 Pain Relevance 0
on LH secretion [105] and GnRH gene expression [106] is
Gene_expression (expression) of GnRH gene
8) Confidence 0.01 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 0.97 Pain Relevance 0

General Comments

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