INT16772

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2011
Negated 6
Speculated 1
Reported most in Body
Documents 81
Total Number 83
Disease Relevance 90.98
Pain Relevance 11.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MPO) extracellular space (MPO) oxidoreductase activity (MPO)
aging (MPO) nucleus (MPO) lysosome (MPO)
Anatomy Link Frequency
neutrophils 11
monocytes 4
eosinophil 3
plaques 3
plasma 2
MPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 913 99.92 Very High Very High Very High
Inflammatory response 43 99.58 Very High Very High Very High
cytokine 119 99.32 Very High Very High Very High
Angina 302 99.28 Very High Very High Very High
rheumatoid arthritis 407 98.64 Very High Very High Very High
Bioavailability 36 96.96 Very High Very High Very High
ischemia 106 96.48 Very High Very High Very High
eye pain 1 96.44 Very High Very High Very High
imagery 115 95.72 Very High Very High Very High
nociceptor 2 95.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1785 100.00 Very High Very High Very High
Cramps 1 100.00 Very High Very High Very High
Acute Coronary Syndrome 658 99.96 Very High Very High Very High
INFLAMMATION 979 99.92 Very High Very High Very High
Atherosclerosis 230 99.92 Very High Very High Very High
Myocardial Infarction 381 99.78 Very High Very High Very High
Coronary Artery Disease 394 99.76 Very High Very High Very High
Leukocytosis 7 99.72 Very High Very High Very High
Atherosclerotic Plaque 96 99.60 Very High Very High Very High
Rupture 61 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myeloperoxidase (MPO) expressed in human atherosclerotic plaques has been suggested to be operative in vivo, making LDL atherogenic.
Gene_expression (expressed) of Myeloperoxidase in plaques associated with atherosclerotic plaque and urological neuroanatomy
1) Confidence 0.78 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9409266 Disease Relevance 0.39 Pain Relevance 0.27
Myeloperoxidase (MPO) expressed in human atherosclerotic plaques has been suggested to be operative in vivo, making LDL atherogenic.
Gene_expression (expressed) of MPO in plaques associated with atherosclerotic plaque and urological neuroanatomy
2) Confidence 0.78 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9409266 Disease Relevance 0.39 Pain Relevance 0.27
It is produced from H2O2 and Cl- by the heme enzyme myeloperoxidase (MPO).
Gene_expression (produced) of MPO associated with urological neuroanatomy
3) Confidence 0.68 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1850278 Disease Relevance 0.42 Pain Relevance 0.22
MPO was measured in
Gene_expression (measured) of MPO associated with urological neuroanatomy
4) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.55 Pain Relevance 0
They have found that: (1) ACS rate (36.2%) in the fourth quartile group of MPO level was 6
Gene_expression (level) of MPO associated with acute coronary syndrome and urological neuroanatomy
5) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.34 Pain Relevance 0.09
Of interest in this study, serum MPO levels were associated
Gene_expression (levels) of MPO associated with urological neuroanatomy
6) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.50 Pain Relevance 0.05
The

MPO levels were significantly higher in case subjects than in control subjects

Gene_expression (levels) of MPO associated with urological neuroanatomy
7) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.50 Pain Relevance 0
high MPO levels in the circulation, as compared with those with chronic stable
Gene_expression (levels) of MPO associated with urological neuroanatomy
8) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.82 Pain Relevance 0.37
Therefore, MPO is prevalently
Gene_expression (is) of MPO associated with urological neuroanatomy
9) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.62 Pain Relevance 0.36
times higher than that in the first quartile group of MPO level, P < .01.

(2) Gensini score in the fourth quartile group of MPO level was significantly higher

Gene_expression (level) of MPO associated with urological neuroanatomy
10) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.30 Pain Relevance 0.04
In ACS, MPO has been consistently found to be
Gene_expression (be) of MPO associated with acute coronary syndrome and urological neuroanatomy
11) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.71 Pain Relevance 0.28
Risk

of future CAD increased in consecutive quartiles of MPO concentration, with an

Gene_expression (concentration) of MPO associated with coronary artery disease and urological neuroanatomy
12) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.47 Pain Relevance 0
have investigated the long-term prognostic significance of baseline MPO levels
Gene_expression (levels) of MPO associated with urological neuroanatomy
13) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.62 Pain Relevance 0
times higher than that in the first quartile group of MPO level, P < .01.

(2) Gensini score in the fourth quartile group of MPO level was significantly higher

Gene_expression (level) of MPO associated with urological neuroanatomy
14) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.38 Pain Relevance 0.04
In particular all studies involving MPO assessment have used
Gene_expression (assessment) of MPO associated with urological neuroanatomy
15) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.91 Pain Relevance 0.15
The potential usefulness for risk stratification of blood concentrations of MPO was
Gene_expression (concentrations) of MPO in blood associated with urological neuroanatomy
16) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.29 Pain Relevance 0
In addition, MPO content can be measured in
Gene_expression (content) of MPO associated with urological neuroanatomy
17) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.49 Pain Relevance 0.06
We studied the presence of proteinase 3 (PR3), myeloperoxidase (MPO) and elastase (HLE) on the plasma membrane of neutrophils in patients with biopsy-proven Wegener's disease (WG), pANCA-positive vasculitis, control patients (SLE, rheumatoid arthritis, ankylosing spondylitis), sepsis patients and healthy donors.
Gene_expression (presence) of MPO in neutrophils associated with spinal inflammation, rheumatoid arthritis, urological neuroanatomy, systemic lupus erythematosus, vasculitis, disease and sepsis
18) Confidence 0.65 Published 1993 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8296655 Disease Relevance 1.12 Pain Relevance 0.14
Therefore, it is conceivable that on days with elevated PM levels, there is increased MPO production, resulting in less NO production from endothelial cells and thus a decrease in endothelial function.
Gene_expression (production) of MPO in endothelial cells associated with urological neuroanatomy
19) Confidence 0.64 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 1.05 Pain Relevance 0.08
Advanced human atherosclerotic plaques from patients with sudden cardiac death, strongly expressed MPO at sites of rupture.
Gene_expression (expressed) of MPO in plaques associated with atherosclerotic plaque, rupture, urological neuroanatomy and myocardial infarction
20) Confidence 0.63 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716784 Disease Relevance 1.88 Pain Relevance 0.11

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