INT167747

Context Info Confidence 0.45 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.41 Pain Relevance 0.11

DNA binding (Nfkb1, Nfe2l2) cytoplasm (Nfkb1, Nfe2l2) nucleus (Nfkb1, Nfe2l2) mitochondrion (Nfkb1) protein complex (Nfkb1) cytosol (Nfkb1)

Nfkb1 (Mus musculus) Nfe2l2 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate 1 74.84 Paracetamol 1 70.12

Disease Link Frequency Relevance Heat Toxicity 2 99.32 Stress 5 86.56 Injury 1 41.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, increased Nrf2 caused by Keap1 depletion was reversed by co-depletion of NF-kappaB.

Negative_regulation (depletion) of NF-kappaB Negative_regulation (reversed) of Positive_regulation (increased) of Nrf2

1) Confidence 0.45 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.41 Pain Relevance 0.11

General Comments

This test has worked.