INT167751

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Context Info
Confidence 0.77
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 8.56
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (DSPP) proteinaceous extracellular matrix (DSPP)
Anatomy Link Frequency
dentin 4
dentine 3
odontoblasts 1
extracellular matrix 1
lung 1
DSPP (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 98.24 Very High Very High Very High
antagonist 4 78.48 Quite High
Inflammation 58 73.44 Quite High
pulpitis 4 50.00 Quite Low
bradykinin 4 22.88 Low Low
substance P 5 21.68 Low Low
Pain 32 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cleidocranial Dysplasia 513 98.70 Very High Very High Very High
Dentinogenesis Imperfecta 774 98.04 Very High Very High Very High
Hyperglycemia 1 89.24 High High
Infection 34 88.32 High High
Shock 2 88.00 High High
Sensorineural Hearing Loss 18 80.00 Quite High
Diabetes Mellitus 20 74.88 Quite High
Smear Layer 11 74.56 Quite High
Osteogenesis Imperfecta 135 73.80 Quite High
INFLAMMATION 56 73.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bone defects appear to be absent from individuals with dentine disorders involving mutations of DSPP despite DSPP expression in this tissue.
Gene_expression (expression) of DSPP in dentine
1) Confidence 0.77 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 0.23 Pain Relevance 0
DSPP is expressed in a number of tissues including bone, kidney, salivary gland and lung but its expression in dentine is hundreds of times higher than in other tissues [5,18-22].
Gene_expression (expressed) of DSPP in lung
2) Confidence 0.77 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 1.21 Pain Relevance 0
This may be due to the low expression level of DSPP in bone [18], altered proteolytic processing [41,42] or molecular redundancy involving other extracellular matrix proteins found in bone [1].
Gene_expression (expression) of DSPP in extracellular matrix
3) Confidence 0.67 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 0.24 Pain Relevance 0
Recent reports suggest that the DPP peptide length varies considerably as the result of in-frame insertion/deletions and single nucleotide length polymorphisms within the highly repetitive, and redundant, DPP portion of the DSPP gene [26-28].
Gene_expression (portion) of DSPP
4) Confidence 0.67 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 0.16 Pain Relevance 0
The only mutations causative of DGI and DD, with the exception of DD-I for which the underlying mutation(s) has been elucidated, are found in the dentine sialophosphoprotein gene (DSPP), suggesting that these conditions are indeed allelic (Table 1).
Neg (exception) Gene_expression (found) of DSPP in dentine associated with cleidocranial dysplasia and dentinogenesis imperfecta
5) Confidence 0.67 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 1.49 Pain Relevance 0
Recent reports suggest that the DPP peptide length varies considerably as the result of in-frame insertion/deletions and single nucleotide length polymorphisms within the highly repetitive, and redundant, DPP portion of the DSPP gene [26-28].
Gene_expression (portion) of DPP
6) Confidence 0.58 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 0.16 Pain Relevance 0
The only mutations causative of DGI and DD, with the exception of DD-I for which the underlying mutation(s) has been elucidated, are found in the dentine sialophosphoprotein gene (DSPP), suggesting that these conditions are indeed allelic (Table 1).
Neg (exception) Gene_expression (found) of dentine sialophosphoprotein gene in dentine associated with cleidocranial dysplasia and dentinogenesis imperfecta
7) Confidence 0.58 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 1.49 Pain Relevance 0
RESULTS: Cells from the diseased group demonstrated decreased colony formation capacity and a slightly decreased cell proliferation rate, but they had similar STRO-1 expression and exhibited a similar percentage of positive ex vivo osteogenic induction and dentin sialophosphoprotein expression from STRO-1-enriched pulp cells.
Gene_expression (expression) of sialophosphoprotein in dentin
8) Confidence 0.33 Published 2010 Journal J Endod Section Body Doc Link 20416426 Disease Relevance 0 Pain Relevance 0
DSPP is expressed in a number of tissues including bone, kidney, salivary gland and lung but its expression in dentine is hundreds of times higher than in other tissues [5,18-22].
Gene_expression (expressed) of DSPP in kidney
9) Confidence 0.26 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 1.21 Pain Relevance 0
DSPP is expressed in a number of tissues including bone, kidney, salivary gland and lung but its expression in dentine is hundreds of times higher than in other tissues [5,18-22].
Gene_expression (expressed) of DSPP in salivary gland
10) Confidence 0.26 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 1.21 Pain Relevance 0
The family includes DPP7, DPP8, DPP9, DPP-IV-?
Gene_expression (includes) of DPP
11) Confidence 0.08 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877018 Disease Relevance 0.52 Pain Relevance 0.08
Enamel is the hardest nonvital mineralized tissue, dentin is the hardest vital tissue and the pulp is a specialized connective tissue lined by dedicated end-stage odontoblasts that produce dentin throughout the life of the tooth, in which the pulp chamber becomes smaller over time.
Gene_expression (produce) of dentin in odontoblasts
12) Confidence 0.04 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2913523 Disease Relevance 0.15 Pain Relevance 0
The deeper affected carious dentin is generally 1,000 to 2,500 ?
Gene_expression (is) of dentin in dentin
13) Confidence 0.03 Published 2010 Journal International Journal of Dentistry Section Body Doc Link PMC2913523 Disease Relevance 0.14 Pain Relevance 0.10
During primary tooth formation, dentin is produced by odontoblastic cells located within the pulp.
Gene_expression (produced) of dentin in tooth
14) Confidence 0.02 Published 2006 Journal Head Face Med Section Body Doc Link PMC1481630 Disease Relevance 0.07 Pain Relevance 0
In one rat model [32], pulp capping with MTA produced significantly more dentin sialophosphoprotein (DSP), a marker of dentinoblast differentiation, compared to recombinant BMP-7.
Gene_expression (produced) of dentin in dentin
15) Confidence 0.02 Published 2006 Journal Head Face Med Section Body Doc Link PMC1481630 Disease Relevance 0.19 Pain Relevance 0.06
Based on histological and scanning electron microscope analyses it could be concluded that DIAGNOdent and visual tactile examination can detect the remaining dentin as sound after bur excavation.
Gene_expression (detect) of dentin in dentin
16) Confidence 0.01 Published 2008 Journal European Journal of Dentistry Section Body Doc Link PMC2635900 Disease Relevance 0.07 Pain Relevance 0

General Comments

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