INT167760

Context Info Confidence 0.32 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.42 Pain Relevance 0.68

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1) endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)

Anatomy Link Frequency spinal cord dorsal horn 2 Sigmar1 (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 5 99.08 nMDA receptor 2 98.88 Spinal cord 1 97.28 Dorsal horn 1 96.80 agonist 2 94.48 intrathecal 3 92.40 potassium channel 6 84.52 Pain 7 78.16 withdrawal 1 63.76 fortral 6 5.00

Disease Link Frequency Relevance Heat Nociception 1 95.88 Adhesions 10 94.08 Pain 5 78.16 Metastasis 2 73.36 Cancer 2 5.00 Attention Deficit Hyperactivity Disorder 1 5.00 Psychosis 1 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We also showed that activation of spinal sigma-1 receptors increased the phosphorylation of the NMDA receptor NR1 subunit (pNR1) in the spinal cord dorsal horn, which resulted in the potentiation of NMDA receptor function.

Positive_regulation (increased) of Positive_regulation (activation) of sigma-1 in spinal cord dorsal horn associated with nmda receptor, dorsal horn and spinal cord

1) Confidence 0.32 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.17 Pain Relevance 0.64

Only sigma-1 receptor ligands, however, resulted in an increase of sigma-1 receptors in the FAC, independent of talin.

Positive_regulation (resulted) of Positive_regulation (increase) of sigma-1

2) Confidence 0.29 Published 2007 Journal J Mol Signal Section Abstract Doc Link PMC2045653 Disease Relevance 0.25 Pain Relevance 0.04

General Comments

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