INT167760

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
spinal cord dorsal horn 2
Sigmar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 5 99.08 Very High Very High Very High
nMDA receptor 2 98.88 Very High Very High Very High
Spinal cord 1 97.28 Very High Very High Very High
Dorsal horn 1 96.80 Very High Very High Very High
agonist 2 94.48 High High
intrathecal 3 92.40 High High
potassium channel 6 84.52 Quite High
Pain 7 78.16 Quite High
withdrawal 1 63.76 Quite High
fortral 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 1 95.88 Very High Very High Very High
Adhesions 10 94.08 High High
Pain 5 78.16 Quite High
Metastasis 2 73.36 Quite High
Cancer 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low
Psychosis 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also showed that activation of spinal sigma-1 receptors increased the phosphorylation of the NMDA receptor NR1 subunit (pNR1) in the spinal cord dorsal horn, which resulted in the potentiation of NMDA receptor function.
Positive_regulation (increased) of Positive_regulation (activation) of sigma-1 in spinal cord dorsal horn associated with nmda receptor, dorsal horn and spinal cord
1) Confidence 0.32 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.17 Pain Relevance 0.64
Only sigma-1 receptor ligands, however, resulted in an increase of sigma-1 receptors in the FAC, independent of talin.
Positive_regulation (resulted) of Positive_regulation (increase) of sigma-1
2) Confidence 0.29 Published 2007 Journal J Mol Signal Section Abstract Doc Link PMC2045653 Disease Relevance 0.25 Pain Relevance 0.04

General Comments

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