INT167761

Context Info Confidence 0.46 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0.22 Pain Relevance 0.88

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1) endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)

Anatomy Link Frequency spinal 1 Sigmar1 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 6 100.00 intrathecal 3 95.32 agonist 2 93.08 Kinase C 5 89.04 nMDA receptor 2 84.24 Spinal cord 1 82.64 Dorsal horn 1 82.16 withdrawal 1 67.24

Disease Link Frequency Relevance Heat Nociception 1 91.84 Pain 4 74.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Sigma-1 receptor-induced increase in murine spinal NR1 phosphorylation is mediated by the PKCalpha and epsilon, but not the PKCzeta, isoforms.

Phosphorylation (phosphorylation) of Sigma-1 receptor in spinal associated with pain

1) Confidence 0.46 Published 2010 Journal Neurosci. Lett. Section Title Doc Link 20417251 Disease Relevance 0.22 Pain Relevance 0.88

General Comments

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