INT167769

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.86
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Prkca, Sigmar1) nucleus (Prkca, Sigmar1) plasma membrane (Prkca, Sigmar1)
transport (Sigmar1) nuclear envelope (Sigmar1) mitochondrion (Prkca)
Anatomy Link Frequency
spinal 6
Prkca (Mus musculus)
Sigmar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 18 100.00 Very High Very High Very High
Kinase C 15 100.00 Very High Very High Very High
intrathecal 9 96.44 Very High Very High Very High
agonist 6 94.20 High High
nMDA receptor 6 85.36 High High
Spinal cord 3 83.76 Quite High
Dorsal horn 3 83.28 Quite High
withdrawal 3 79.32 Quite High
Disease Link Frequency Relevance Heat
Pain 12 97.96 Very High Very High Very High
Nociception 3 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings demonstrate that the sigma-1 receptor-induced increase in spinal pNR1 expression is mediated by the PKCalpha and PKC epsilon isoforms, which in turn contribute to the pain facilitation phenomenon.
PKCalpha Positive_regulation (mediated) of Positive_regulation (increase) of sigma-1 receptor in spinal associated with pain and kinase c
1) Confidence 0.38 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.31 Pain Relevance 0.87
Sigma-1 receptor-induced increase in murine spinal NR1 phosphorylation is mediated by the PKCalpha and epsilon, but not the PKCzeta, isoforms.
PKCalpha Positive_regulation (mediated) of Positive_regulation (increase) of Sigma-1 receptor in spinal associated with pain
2) Confidence 0.38 Published 2010 Journal Neurosci. Lett. Section Title Doc Link 20417251 Disease Relevance 0.23 Pain Relevance 0.89
These findings demonstrate that the sigma-1 receptor-induced increase in spinal pNR1 expression is mediated by the PKCalpha and PKC epsilon isoforms, which in turn contribute to the pain facilitation phenomenon.
PKC Positive_regulation (mediated) of Positive_regulation (increase) of sigma-1 receptor in spinal associated with pain and kinase c
3) Confidence 0.33 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.31 Pain Relevance 0.87

General Comments

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