INT167770

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.34
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Sigmar1, Prkcz) nucleus (Sigmar1, Prkcz) plasma membrane (Sigmar1, Prkcz)
endosome (Prkcz) transport (Sigmar1) endoplasmic reticulum (Sigmar1)
Anatomy Link Frequency
spinal 1
Sigmar1 (Mus musculus)
Prkcz (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 6 98.52 Very High Very High Very High
Kinase C 5 96.12 Very High Very High Very High
intrathecal 3 75.96 Quite High
withdrawal 1 71.64 Quite High
agonist 2 68.88 Quite High
nMDA receptor 2 58.88 Quite High
Dorsal horn 1 56.76 Quite High
Spinal cord 1 56.28 Quite High
Disease Link Frequency Relevance Heat
Pain 4 98.52 Very High Very High Very High
Nociception 1 47.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, the sigma-1 receptor activation of the PKCzeta isoform appears to be involved in a pain signaling pathway that is independent of spinal pNR1 modulation.
sigma-1 receptor Positive_regulation (activation) of PKCzeta in spinal associated with pain
1) Confidence 0.04 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417251 Disease Relevance 0.34 Pain Relevance 0.77

General Comments

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