INT167815

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Context Info
Confidence 0.65
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.59
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Tpi1) cytosol (Tpi1) nucleus (Tpi1)
embryo development (Tpi1) carbohydrate metabolic process (Tpi1)
Anatomy Link Frequency
embryos 2
Tpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 8 97.92 Very High Very High Very High
antinociception 2 97.64 Very High Very High Very High
withdrawal 4 95.52 Very High Very High Very High
Analgesic 6 84.56 Quite High
Opioid 2 78.56 Quite High
antagonist 4 78.00 Quite High
narcan 2 77.04 Quite High
Morphine 2 63.36 Quite High
Kappa opioid receptor 2 59.52 Quite High
cva 10 57.64 Quite High
Disease Link Frequency Relevance Heat
Embryonic Lethality 40 99.08 Very High Very High Very High
Sprains And Strains 99 87.36 High High
Urinary Tract Infection 78 86.24 High High
Anaemia 70 82.72 Quite High
Hemorrhage 10 57.64 Quite High
Congenital Anomalies 20 54.64 Quite High
Infection 42 54.08 Quite High
Respiratory Failure 2 50.72 Quite High
Apoptosis 71 5.00 Very Low Very Low Very Low
Calcification 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From these data, two fully defined individual compounds (TPI 1818-101 and TPI 1818-109) were synthesized.
Gene_expression (synthesized) of TPI
1) Confidence 0.65 Published 2010 Journal AAPS J Section Abstract Doc Link 20422341 Disease Relevance 0.05 Pain Relevance 0.71
From these data, two fully defined individual compounds (TPI 1818-101 and TPI 1818-109) were synthesized.
Gene_expression (synthesized) of TPI
2) Confidence 0.65 Published 2010 Journal AAPS J Section Abstract Doc Link 20422341 Disease Relevance 0.05 Pain Relevance 0.71
5/+, PiT1neo/neo and PiT1?
Gene_expression (/) of PiT1neo
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.29 Pain Relevance 0
5 embryos represented 6% of normal levels whereas PiT2 expression was increased, as was seen in PiT1neo/neo and PiT1?
Gene_expression (/) of PiT1neo in embryos
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.24 Pain Relevance 0
Similarly, PiT1neo/?
Gene_expression (/) of PiT1neo
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.24 Pain Relevance 0
5 and PiT1+/+ embryos (Fig. 9A and B), or later in development between E15.5 PiT1neo/?
Gene_expression (/) of PiT1neo in embryos
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.06 Pain Relevance 0.03
Wild-type PiT1 mRNA levels in E12.5 PiT1neo/?
Gene_expression (/) of PiT1neo
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.24 Pain Relevance 0
The central metabolic pathways of gluconeogenesis and the TCA cycle are required for UPEC fitness in the murine urinary tract [26] and sdhB, pckA and tpiA, encoding enzymes in these pathways, although downregulated compared to growth in vitro, were nonetheless expressed in all patient isolates (Fig. 2A).
Gene_expression (expressed) of tpiA
8) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2978726 Disease Relevance 0.44 Pain Relevance 0

General Comments

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