INT167819

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fst) nucleus (Fst) cytoplasm (Fst)
IFNA1 (Homo sapiens)
Fst (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 9 99.30 Very High Very High Very High
antagonist 3 98.62 Very High Very High Very High
agonist 2 97.34 Very High Very High Very High
antidepressant 4 95.74 Very High Very High Very High
depression 3 65.68 Quite High
sSRI 1 45.88 Quite Low
Serotonin 1 44.60 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 1 41.68 Quite Low
Depression 3 41.20 Quite Low
Cancer 1 38.20 Quite Low
Viral Infection 1 37.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further investigations showed that fluoxetine combined with WAY 100635 and 8-OH-DPAT failed to produce antidepressant effects in the FST. (4) Co-application of CGS 12066A (5-HT(1B) receptor agonist, CAS 109028-09-3) or GR 127935 (5-HT(1B/1D) receptor antagonist, CAS 148642-42-6) with fluoxetine had no synergistic effects on the IFN-alpha-induced increase of immobility time in FST. (5) Interestingly, co-administration of GR 127935, WAY 100635 and fluoxetine significantly reduced the IFN-alpha-induced increase in immobility time of FST, being more effective than co-administration of WAY 100635 and fluoxetine.
IFN-alpha Positive_regulation (increase) of FST associated with antidepressant, antagonist, agonist and fluoxetine
1) Confidence 0.39 Published 2010 Journal Arzneimittelforschung Section Abstract Doc Link 20422941 Disease Relevance 0 Pain Relevance 1.07

General Comments

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