INT16782

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Context Info
Confidence 0.10
First Reported 1987
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 19
Disease Relevance 8.23
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (ERLEC1)
Anatomy Link Frequency
urine 3
photoreceptor 3
erythrocyte 1
brain 1
epithelium 1
ERLEC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Immobilon 2 100.00 Very High Very High Very High
Opioid 4 99.60 Very High Very High Very High
Chronic pancreatitis 8 98.20 Very High Very High Very High
medulla 4 96.52 Very High Very High Very High
spastic colon 1 95.52 Very High Very High Very High
interstitial cystitis 6 88.60 High High
Pain 5 84.12 Quite High
cytokine 17 82.76 Quite High
Inflammatory response 4 67.92 Quite High
Clonidine 2 67.52 Quite High
Disease Link Frequency Relevance Heat
Ocular Toxicity (including Many Sub-types) 152 99.84 Very High Very High Very High
Cold Sores 15 99.70 Very High Very High Very High
Adenocarcinoma 5 99.44 Very High Very High Very High
Ovarian Cancer 116 98.68 Very High Very High Very High
Pancreatitis 8 98.20 Very High Very High Very High
Pancreatic Cancer 4 97.16 Very High Very High Very High
Cancer 77 96.38 Very High Very High Very High
Functional Bowel Disorder 1 95.52 Very High Very High Very High
Malignant Neoplastic Disease 7 94.04 High High
Inflammatory Bowel Disease 3 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction with lectin of kappa opioid binding sites solubilized from human placenta.
lectin Binding (Interaction) of in placenta associated with opioid and immobilon
1) Confidence 0.10 Published 1987 Journal Life Sci. Section Title Doc Link 3027488 Disease Relevance 0 Pain Relevance 0.45
Tn antigen, recognized by Vicia villosa lectin, was expressed by all specimens of normal pancreas (acinar cells) and pancreatic cancers and all but one case of chronic pancreatitis.
lectin Binding (recognized) of in acinar cells associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.09 Published 1991 Journal Gastroenterology Section Abstract Doc Link 1850375 Disease Relevance 0.74 Pain Relevance 0.33
Lectin binding led to an increase in erythrocyte membrane permeability to sodium and potassium, the former resulting in an influx of water and subsequent haemolysis.
Lectin Binding (binding) of in erythrocyte
3) Confidence 0.09 Published 2002 Journal Br. J. Haematol. Section Abstract Doc Link 12181064 Disease Relevance 0.09 Pain Relevance 0.07
Lectin binding in colorectal mucosa.
Lectin Binding (binding) of
4) Confidence 0.07 Published 1989 Journal Indian J Gastroenterol Section Title Doc Link 2914716 Disease Relevance 0.64 Pain Relevance 0.10
The study of the interaction of [3H]idazoxan binding sites with heparin and lectins (soybean and lentil lectin) confirm the heterogeneity of these sites in the human brain.
lectin Binding (interaction) of in brain
5) Confidence 0.06 Published 1997 Journal Fundam Clin Pharmacol Section Abstract Doc Link 9182078 Disease Relevance 0 Pain Relevance 0.22
This study demonstrated that HSV-1 and -2 both interact with the DC-specific C-type lectin DC-SIGN.
lectin Binding (interact) of associated with cold sores
6) Confidence 0.04 Published 2008 Journal J. Gen. Virol. Section Abstract Doc Link 18796707 Disease Relevance 1.73 Pain Relevance 0.08
Further confirmation of the altered levels of CD59, kininogen-1 and fragments of ITIH4 and albumin in the urine of patients with ovarian carcinoma relative to those of the control subjects was performed using antibodies and a lectin that bind to the respective proteins that were blotted onto membranes.
lectin Binding (bind) of in urine associated with ovarian cancer
7) Confidence 0.02 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.45 Pain Relevance 0
Their different altered levels in the urine of ovarian cancer patients were confirmed by Western blotting using antisera and a lectin that bind to the respective proteins.
lectin Binding (bind) of in urine associated with ovarian cancer
8) Confidence 0.02 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.41 Pain Relevance 0
Proteins that were aberrantly excreted by the cancer patients, relative to control subjects, were identified by mass spectrometry and their altered levels in the patients urine were confirmed by Western blotting using antisera and a lectin that bind to the respective proteins.


lectin Binding (bind) of in urine associated with cancer
9) Confidence 0.02 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 0.68 Pain Relevance 0
The different altered levels of the proteins were confirmed by Western blotting using antisera and a lectin that bind to the respective proteins.


lectin Binding (bind) of
10) Confidence 0.02 Published 2010 Journal Proteome Sci Section Abstract Doc Link PMC2998473 Disease Relevance 0.47 Pain Relevance 0
For example, markers previously used to prove endothelial identity of putative progenitors, such as CD31, lectin binding or LDL accumulation are now known to be non-specific for the endothelial lineage, but also characteristic for cells of haematopoietic origin] [111,112].
lectin Binding (binding) of
11) Confidence 0.01 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2834645 Disease Relevance 0 Pain Relevance 0
We have examined the endogenous lectin associated with bladder epithelium by immunohistochemistry using biotinylated neoglycoconjugates.
lectin Spec (examined) Binding (associated) of in epithelium
12) Confidence 0.01 Published 2001 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 14533792 Disease Relevance 0.33 Pain Relevance 0.17
This study thus shows that, overall, there are striking similarities between the lectin binding of drusen, RPE cells, and the photoreceptor outer segments, though cone outer segments were somewhat distinct in some features of their O-linked glycosylation.
lectin Binding (binding) of in photoreceptor associated with ocular toxicity (including many sub-types)
13) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2676197 Disease Relevance 0.53 Pain Relevance 0
Overall, there were striking similarities between the lectin binding of drusen, retinal pigment epithelium, and the photoreceptor outer segments, though cone outer segments were distinct in some features of their O-linked glycosylation.


lectin Binding (binding) of in photoreceptor associated with ocular toxicity (including many sub-types)
14) Confidence 0.01 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2676197 Disease Relevance 0.71 Pain Relevance 0
Sections were washed and sites of lectin binding revealed with 0.05% (w/v) diaminobenzidine tetrahydrochloride dihydrate (Aldrich Chemical Co., Gillingham, UK) in 0.05 M TBS, pH 7.6, and 0.015% (v/v) hydrogen peroxide (100 volumes) for 5 min at 18 °C±0.5 °C.
lectin Binding (binding) of
15) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2676197 Disease Relevance 0 Pain Relevance 0
Comparison of lectin binding of drusen, RPE, Bruch’s membrane, and photoreceptors

Purpose

lectin Binding (binding) of in photoreceptors associated with ocular toxicity (including many sub-types)
16) Confidence 0.01 Published 2009 Journal Molecular Vision Section Title Doc Link PMC2676197 Disease Relevance 0.64 Pain Relevance 0
Two other genes upstream and downstream of this branch did not associate (soluble mannose-binding lectin (protein C) 2 (MBL2) and factor II [FII]).
lectin Neg (not) Binding (associate) of
17) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.37 Pain Relevance 0.14
Two other genes upstream and downstream of this branch did not associate (soluble mannose-binding lectin (protein C) 2 (MBL2) and factor II [FII]).
lectin Binding (binding) of
18) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.37 Pain Relevance 0.14
Typically, these cells can bind and translocate macromolecular material, bacteria, and lectin into underlying lymphocytes, and even cervical lymph nodes.
lectin Binding (bind) of in lymphocytes
19) Confidence 0.01 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2765629 Disease Relevance 0.07 Pain Relevance 0

General Comments

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