INT167853

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.80
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
AMs 6
Mat1a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 22 99.92 Very High Very High Very High
substance P 42 98.52 Very High Very High Very High
c fibre 3 91.92 High High
Inflammation 32 90.84 High High
Hippocampus 2 50.84 Quite High
isoflurane 6 18.32 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronavirus Infection 56 98.04 Very High Very High Very High
Severe Acute Respiratory Syndrome 76 97.88 Very High Very High Very High
Disease 86 95.48 Very High Very High Very High
Infection 86 93.00 High High
INFLAMMATION 34 90.84 High High
Stress 1 90.12 High High
Sprains And Strains 10 84.96 Quite High
Aging 19 73.96 Quite High
Cancer 2 69.76 Quite High
Pox Virus Infection 2 59.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This could have explained the high-AdoMet levels; however, the AdoMet levels in the 8-month-old APP/PS1 mice in our study, should have been increased compared to 8-month-old wild types, and that was not the case.
Positive_regulation (increased) of Gene_expression (levels) of AdoMet
1) Confidence 0.35 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.46 Pain Relevance 0.03
Treatment with TLR agonists to activate AMs and rDCs or transfer of activated BMDCs also prevents a lethal outcome.
Positive_regulation (transfer) of Gene_expression (transfer) of AMs associated with agonist
2) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.67 Pain Relevance 0.10
Treatment with TLR agonists to activate AMs and rDCs or transfer of activated BMDCs also prevents a lethal outcome.
Positive_regulation (activate) of Gene_expression (transfer) of AMs associated with agonist
3) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.68 Pain Relevance 0.10
Our results suggest that CS produces AMs' NK1R overexpression primarily by both promoting neurogenic SP release and synergizing NK1R response to neurogenic SP largely via activating NF-kappaB pathway.
Positive_regulation (produces) of Gene_expression (overexpression) of AMs in AMs associated with substance p
4) Confidence 0.17 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.61
Neurokinin 1 receptors (NK1Rs) in alveolar macrophages (AMs) are overexpressed by cigarette smoke (CS) in vivo and substance P (SP) in vitro.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of AMs in AMs associated with substance p
5) Confidence 0.17 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.45
Our results suggest that CS produces AMs' NK1R overexpression primarily by both promoting neurogenic SP release and synergizing NK1R response to neurogenic SP largely via activating NF-kappaB pathway.
Positive_regulation (overexpression) of Gene_expression (overexpression) of AMs in AMs associated with substance p
6) Confidence 0.17 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.61

General Comments

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