INT167853

Context Info Confidence 0.35 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 3.80 Pain Relevance 1.88

Anatomy Link Frequency AMs 6 Mat1a (Mus musculus)

Pain Link Frequency Relevance Heat agonist 22 99.92 substance P 42 98.52 c fibre 3 91.92 Inflammation 32 90.84 Hippocampus 2 50.84 isoflurane 6 18.32 cytokine 12 5.00 anesthesia 3 5.00 adenocard 2 5.00 Inflammatory response 2 5.00

Disease Link Frequency Relevance Heat Coronavirus Infection 56 98.04 Severe Acute Respiratory Syndrome 76 97.88 Disease 86 95.48 Infection 86 93.00 INFLAMMATION 34 90.84 Stress 1 90.12 Sprains And Strains 10 84.96 Aging 19 73.96 Cancer 2 69.76 Pox Virus Infection 2 59.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This could have explained the high-AdoMet levels; however, the AdoMet levels in the 8-month-old APP/PS1 mice in our study, should have been increased compared to 8-month-old wild types, and that was not the case.

Positive_regulation (increased) of Gene_expression (levels) of AdoMet

1) Confidence 0.35 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.46 Pain Relevance 0.03

Treatment with TLR agonists to activate AMs and rDCs or transfer of activated BMDCs also prevents a lethal outcome.

Positive_regulation (transfer) of Gene_expression (transfer) of AMs associated with agonist

2) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.67 Pain Relevance 0.10

Treatment with TLR agonists to activate AMs and rDCs or transfer of activated BMDCs also prevents a lethal outcome.

Positive_regulation (activate) of Gene_expression (transfer) of AMs associated with agonist

3) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.68 Pain Relevance 0.10

Our results suggest that CS produces AMs' NK1R overexpression primarily by both promoting neurogenic SP release and synergizing NK1R response to neurogenic SP largely via activating NF-kappaB pathway.

Positive_regulation (produces) of Gene_expression (overexpression) of AMs in AMs associated with substance p

4) Confidence 0.17 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.61

Neurokinin 1 receptors (NK1Rs) in alveolar macrophages (AMs) are overexpressed by cigarette smoke (CS) in vivo and substance P (SP) in vitro.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of AMs in AMs associated with substance p

5) Confidence 0.17 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.45

Our results suggest that CS produces AMs' NK1R overexpression primarily by both promoting neurogenic SP release and synergizing NK1R response to neurogenic SP largely via activating NF-kappaB pathway.

Positive_regulation (overexpression) of Gene_expression (overexpression) of AMs in AMs associated with substance p

6) Confidence 0.17 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.61

General Comments

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