INT167856

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 74
Total Number 75
Disease Relevance 39.29
Pain Relevance 23.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Anatomy Link Frequency
bone marrow 6
node 2
ganglion cell layer 2
rod bipolar cell 2
macrophages 1
Nfasc (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 14 99.74 Very High Very High Very High
methotrexate 736 99.28 Very High Very High Very High
rheumatoid arthritis 3542 99.20 Very High Very High Very High
Osteoarthritis 782 98.94 Very High Very High Very High
cytokine 174 98.60 Very High Very High Very High
Inflammation 357 98.12 Very High Very High Very High
Central nervous system 473 96.36 Very High Very High Very High
sodium channel 355 96.36 Very High Very High Very High
metalloproteinase 874 94.20 High High
Spinal cord 94 91.44 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 262 100.00 Very High Very High Very High
Adhesions 173 100.00 Very High Very High Very High
Infection 540 99.72 Very High Very High Very High
Rheumatoid Arthritis 3542 99.20 Very High Very High Very High
Ganglion Cysts 84 99.08 Very High Very High Very High
Osteoarthritis 782 98.94 Very High Very High Very High
INFLAMMATION 459 98.12 Very High Very High Very High
Diabetes Mellitus 154 97.76 Very High Very High Very High
Cytomegalovirus Infection 21 96.88 Very High Very High Very High
Congenital Anomalies 191 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, Nfasc and Trpm1 are expressed in a minority of cells expressing the rod bipolar cell-enriched gene Pcp2, which could reflect gene expression heterogeneity in these cells.
Gene_expression (expressed) of Nfasc in rod bipolar cell
1) Confidence 0.71 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.18 Pain Relevance 0.03
Nfasc is expressed in bipolar cells and the amacrine and the ganglion cell layer, and it was detected in dissociated cells in at least some Pcp2-positive cells and a small fraction of Grm6-positive cells.
Gene_expression (expressed) of Nfasc in ganglion cell layer associated with ganglion cysts
2) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.19 Pain Relevance 0
Expression of the cell adhesion molecule Nfasc was found in a subset of bipolar cells and weakly in amacrine cells, photoreceptor cells, and the ganglion cell layer (Fig. 2G).
Gene_expression (Expression) of Nfasc in ganglion cell layer associated with ganglion cysts and adhesions
3) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.52 Pain Relevance 0
Thus, it is possible that Cntn4 and Nfasc function in the formation of bipolar cell axon structure and contacts.
Gene_expression (function) of Nfasc
4) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.20 Pain Relevance 0
Only a small minority of Glul-positive cells was positive with probes for Og9x, Scgn, Cntn4, Car8, 2300002D11Rik, Nfasc, or Trpm1, suggesting that these genes are not found in Müller glial cells at high frequency (Fig. 3, Supplementary Fig. 1, Supplementary Table 1).
Gene_expression (probes) of Nfasc in glial cells
5) Confidence 0.62 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0.13 Pain Relevance 0
Then, we showed that expression of transgenic Nfasc186 on a Neurofascin-null background was fully able to rescue the nodal complex (Fig. 3 A).
Gene_expression (expression) of Nfasc186 associated with targeted disruption
6) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0.27 Pain Relevance 0.23
The limited extension of viability in Neurofascin-null mice expressing transgenic Nfasc186 may reflect their lack of intact axoglial junctions because Caspr-null mice lacking paranodal junctions in the CNS and PNS generally die between P21 and P33 (Bhat et al., 2001).
Gene_expression (expressing) of Neurofascin-null associated with targeted disruption and central nervous system
7) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0.10 Pain Relevance 0.29
Interestingly, Contactin and Caspr were still detectable in paranodal complexes in these mice, whereas Nfasc155 was not (Schafer et al., 2004).
Neg (not) Gene_expression (was) of Nfasc155
8) Confidence 0.58 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0 Pain Relevance 0.30
However, Nfasc155 lacking most of its C terminus can not only reconstitute the adhesion complex but can also cluster nodal proteins, which shows that intracellular signaling mediated via the carboxy terminus of Nfasc155 is not necessary to promote the assembly of the node of Ranvier in the CNS.
Neg (lacking) Gene_expression (lacking) of Nfasc155 in node associated with central nervous system and adhesions
9) Confidence 0.58 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0.27 Pain Relevance 0.04
Reintroduction of Nfasc186 would reduce the dissipation of the complex by anchoring it at the node.
Gene_expression (Reintroduction) of Nfasc186 in node
10) Confidence 0.58 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0 Pain Relevance 0.21
Unlike the Nfasc186 rescue, mice expressing Nfasc155?
Gene_expression (expressing) of Nfasc155
11) Confidence 0.58 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0.22 Pain Relevance 0.53
Unlike the Nfasc186 rescue, mice expressing Nfasc155?
Gene_expression (rescue) of Nfasc186
12) Confidence 0.58 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0.23 Pain Relevance 0.53
The limited extension of viability in Neurofascin-null mice expressing transgenic Nfasc186 may reflect their lack of intact axoglial junctions because Caspr-null mice lacking paranodal junctions in the CNS and PNS generally die between P21 and P33 (Bhat et al., 2001).
Gene_expression (expressing) of Nfasc186 associated with targeted disruption and central nervous system
13) Confidence 0.52 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0.10 Pain Relevance 0.29
IC or when expressing Nfasc186 (91 ± 4 and 96 ± 2%, respectively; mean ± SEM; n = 3 each; Fig. 5 C).
Gene_expression (expressing) of Nfasc186
14) Confidence 0.52 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2442198 Disease Relevance 0.11 Pain Relevance 0.53
Among bipolar cells, Nfasc also appears to be expressed specifically in a subset of rod bipolar cells (Fig. 5M,N).
Gene_expression (expressed) of Nfasc in rod bipolar cells
15) Confidence 0.48 Published 2008 Journal The Journal of Comparative Neurology Section Body Doc Link PMC2665264 Disease Relevance 0 Pain Relevance 0
Neurofascin 186 (NF186) is expressed prenatally on dorsal root ganglia neurons and it may modulate their adhesive interactions with Schwann cells, which express NF155 postnatally and require it for development of axon–glial paranodal junctions.
Gene_expression (expressed) of Neurofascin 186 in Schwann cells
16) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0.26 Pain Relevance 0
However, no association for any allele of the NF- ?
Gene_expression (allele) of NF
17) Confidence 0.26 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.85 Pain Relevance 0
To evaluate the direct effects of CS and SP on the NK1R expression and the involvement of nuclear factor (NF)-kappaB, macrophages were exposed to CS condensate (CSC) and/or SP without or with blocking NK1R or inhibiting NF-kappaB activation in vitro.
Gene_expression (expression) of NF in macrophages associated with substance p
18) Confidence 0.20 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.65
For both Neurofascin and M6a, the protein expression level in wt and Tg940 brain were approximately the same as illustrated in Fig. 4E–F.


Gene_expression (expression) of Neurofascin in brain
19) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2635968 Disease Relevance 0 Pain Relevance 0
Nuclear extracts were assayed for NF-?
Gene_expression (assayed) of NF
20) Confidence 0.14 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0 Pain Relevance 0

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