INT167858

Context Info Confidence 0.61 First Reported 2009 Last Reported 2010 Negated 3 Speculated 1 Reported most in Body Documents 3 Total Number 7 Disease Relevance 2.97 Pain Relevance 2.33

Anatomy Link Frequency brain 6 AMs 4 Mat1a (Mus musculus)

Pain Link Frequency Relevance Heat substance P 28 99.90 Paracetamol 19 99.40 c fibre 2 98.74 adenocard 8 88.32 Neurotransmitter 4 73.32 Hippocampus 8 32.80 Spinal cord 4 5.00 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Neuroblastoma 8 100.00 Cognitive Disorder 28 97.48 Liver Failure 1 97.08 Disease 152 96.44 Aging 76 95.80 Toxicity 5 91.20 Increased Venous Pressure Under Development 8 57.68 Overdose 1 52.04 Hyperhomocysteinemia 20 49.56 Stress 4 38.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Temporal study of acetaminophen (APAP) and S-adenosyl-L-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity.

Regulation (effects) of Gene_expression (expression) of MAT associated with paracetamol

1) Confidence 0.61 Published 2010 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 20450926 Disease Relevance 0.48 Pain Relevance 1.09

For example, AdoMet administration in human neuroblastoma cells down regulates PS1 gene expression and A?

Regulation (regulates) of Gene_expression (administration) of AdoMet associated with neuroblastoma

2) Confidence 0.34 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.63 Pain Relevance 0.12

Pulmonary SP was increased by CS but almost eliminated by PCF degeneration, which closely correlated to the changes in AMs' NK1R expression.

Regulation (changes) of Gene_expression (expression) of AMs in AMs associated with substance p

3) Confidence 0.21 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.59

In addition, we showed that cholesterol-containing, or DHA-enriched diets did not affect AdoMet or AdoHcy levels in brain tissue of APP/PS1 and wild-type mice.

Neg (not) Regulation (affect) of Gene_expression (levels) of AdoMet in brain

4) Confidence 0.20 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.59 Pain Relevance 0

The finding that cholesterol- or DHA-containing diets do not alter AdoMet or AdoHcy levels in brain tissue of either wild type or APP/PS1 mice, but in contrast do have effects on AD pathology and cerebral hemodynamics [7, 15, 29], suggests that cholesterol- or DHA-containing diets do not influence cerebral hemodynamics or AD pathology via the methylation cycle.

Neg (not) Regulation (alter) of Gene_expression (levels) of AdoMet in brain associated with disease

5) Confidence 0.20 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.64 Pain Relevance 0

Neither a cholesterol- nor a DHA-containing diet did alter AdoMet or AdoHcy levels in brain tissue of 8- and 15-month-old APP/PS1 and wild-type mice as compared to the standard diet (data not shown).

Neg (Neither) Regulation (alter) of Gene_expression (levels) of AdoMet in brain

6) Confidence 0.20 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.63 Pain Relevance 0

Because CS could stimulate pulmonary C-fibers (PCFs) to release SP, we asked whether this neurogenic SP was responsible for AMs' NK1R overexpression during CS.

Spec (whether) Regulation (responsible) of Gene_expression (overexpression) of AMs in AMs associated with c fibre and substance p

7) Confidence 0.15 Published 2010 Journal Exp. Lung Res. Section Abstract Doc Link 20426532 Disease Relevance 0 Pain Relevance 0.52

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