INT167872

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.14
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxp3) intracellular (Foxp3) embryo development (Foxp3)
DNA binding (Foxp3) cytoplasm (Foxp3)
Anatomy Link Frequency
T cells 6
optic 2
Foxp3 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 106 99.98 Very High Very High Very High
Neuritis 6 96.92 Very High Very High Very High
cytokine 88 96.40 Very High Very High Very High
Multiple sclerosis 48 94.24 High High
Inflammatory response 7 93.72 High High
Inflammation 73 91.60 High High
tolerance 8 82.28 Quite High
Central nervous system 67 71.12 Quite High
Neuropeptide 13 70.52 Quite High
antagonist 2 69.44 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 106 99.98 Very High Very High Very High
Immunization 13 99.92 Very High Very High Very High
Optic Neuritis 4 97.16 Very High Very High Very High
Multiple Sclerosis 133 94.24 High High
INFLAMMATION 84 93.32 High High
Neurodegenerative Disease 8 92.56 High High
Chronic Fatigue Syndrome 11 89.80 High High
Motor Neuron Diseases 14 89.44 High High
Disease 72 89.08 High High
Autoimmune Disease 38 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased expression of Foxp3 mRNA and Treg in the optic nerve may play a key role in the development of optic neuritis.
Negative_regulation (Decreased) of Gene_expression (expression) of Foxp3 mRNA in optic associated with optic neuritis and neuritis
1) Confidence 0.50 Published 2010 Journal Int. J. Mol. Med. Section Abstract Doc Link 20428790 Disease Relevance 0.80 Pain Relevance 0.42
inhibited the expression of Foxp3 (Figure 2).
Negative_regulation (inhibited) of Gene_expression (expression) of Foxp3
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.52 Pain Relevance 0.09
The VDR signal on the CD4+ T cells inhibits the expression of IL-17, IL-2, Foxp3, and CCR6 but enhances the expression of IL-10.
Negative_regulation (inhibits) of Gene_expression (expression) of Foxp3 in T cells
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.38 Pain Relevance 0.09
Expression of perforin, granzyme B and Foxp3 in CD8+CD94+T cells was minimal
Negative_regulation (minimal) of Gene_expression (Expression) of Foxp3 in T cells
4) Confidence 0.32 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0
subset actually downregulated Foxp3 expression and started production of IL-17 and IFN-?
Negative_regulation (downregulated) of Gene_expression (expression) of Foxp3
5) Confidence 0.29 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.51 Pain Relevance 0.07
CD4+CD25high Treg cells isolated from patients with active RA express reduced levels of transcription factor forkhead box P3 (FoxP3) – which plays a major role in the function of Treg cells [71,72] – that poorly suppress cytokine secretion from T cells and monocytes, and that do not convey a suppressive phenotype to effector CD4+CD25- T cells [73,74].
Negative_regulation (reduced) of Gene_expression (express) of FoxP3 in T cells associated with rheumatoid arthritis and cytokine
6) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.91 Pain Relevance 0.58
The possibility that PACAP/VIP failure also leads to Treg impairment, possibly through impaired Foxp3 expression, is also yet to be investigated.
Negative_regulation (impaired) of Gene_expression (expression) of Foxp3
7) Confidence 0.21 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.69 Pain Relevance 0.16
Additionally, TLR signaling influences Treg function, in particular, Pam3Cys has been shown to transiently reduce the expression of FoxP3+ in Treg cells and to suppress their activity [40].
Negative_regulation (reduce) of Gene_expression (expression) of FoxP3
8) Confidence 0.07 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.34 Pain Relevance 0.04

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