INT167894

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.96
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PTS) mitochondrion (PTS) small molecule metabolic process (PTS)
lyase activity (PTS) cellular amino acid metabolic process (PTS) cytoplasm (PTS)
Anatomy Link Frequency
T lymphocytes 1
PTS (Homo sapiens)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 1 100.00 Very High Very High Very High
Lasting pain 1 95.76 Very High Very High Very High
headache 8 94.16 High High
Cluster headache 2 87.84 High High
cva 60 86.32 High High
Migraine 5 83.80 Quite High
chemokine 6 65.44 Quite High
cytokine 21 64.84 Quite High
Angina 2 64.72 Quite High
Inflammation 48 64.44 Quite High
Disease Link Frequency Relevance Heat
Syndrome 8 100.00 Very High Very High Very High
Thrombosis 24 97.56 Very High Very High Very High
Pressure And Volume Under Development 2 97.00 Very High Very High Very High
Pain 1 95.76 Very High Very High Very High
Headache 9 94.16 High High
Cluster Headache 2 87.84 High High
Cv General 3 Under Development 23 86.32 High High
Hypertension 4 85.12 High High
Thrombosis Related Under Development 48 78.24 Quite High
Pulmonary Embolism 8 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTS is not reliably prevented by prompt antithrombotic therapy following the diagnosis of DVT.
Negative_regulation (prevented) of PTS associated with syndrome and thrombosis
1) Confidence 0.14 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 2.48 Pain Relevance 0.33
Second, ROS-mediated inhibitory modulation of the activity of PTPs (for example, CD45, SHP-1, HePTP) has been shown to regulate signalling events involved in the activation of T lymphocytes [256,257].
Negative_regulation (modulation) of PTPs in T lymphocytes
2) Confidence 0.13 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.42 Pain Relevance 0.16
Antagonizing the rate limiting cofactor tetrahydrobiopterin seems another very likely new treatment.
Negative_regulation (limiting) of tetrahydrobiopterin associated with tetrahydrobiopterin
3) Confidence 0.06 Published 2010 Journal Neurotherapeutics Section Abstract Doc Link 20430317 Disease Relevance 1.06 Pain Relevance 1.05

General Comments

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