INT167897

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.32
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ppp1r9b) nucleoplasm (Ppp1r9b) plasma membrane (Ppp1r9b)
cytoskeleton (Ppp1r9b) nucleus (Ppp1r9b) cytoplasm (Ppp1r9b)
Anatomy Link Frequency
spines 1
Ppp1r9b (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 2 98.40 Very High Very High Very High
agonist 8 95.04 Very High Very High Very High
withdrawal 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypotension 4 98.20 Very High Very High Very High
Disease 11 5.00 Very Low Very Low Very Low
Nephrotic Syndrome 8 5.00 Very Low Very Low Very Low
Renal Disease 6 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low
Renal Failure 3 5.00 Very Low Very Low Very Low
Chronic Renal Failure 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that eliminating spinophilin expression in native tissues leads to an enhanced receptor/G protein coupling efficiency that contributes to sensitization of receptor mediated responses in vivo.
Gene_expression (expression) of spinophilin
1) Confidence 0.58 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20430865 Disease Relevance 0.15 Pain Relevance 0.22
Mice lacking spinophilin expression display dramatically enhanced and prolonged hypotensive, bradycardic, and sedative-hypnotic responses to alpha(2)AR stimulation.
Gene_expression (expression) of spinophilin associated with hypotension
2) Confidence 0.58 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20430865 Disease Relevance 0.17 Pain Relevance 0.27
It is worth noting in the context of analogies between the podocyte slit diaphragm and neuronal dendrites that numerous mRNAs that encode dendritic proteins are themselves localized to dendritic spines where they appear to be dynamically translated at their sites of expression [60] Just as a number of the proteins encoded by these mRNA are localized to dendrites, it is also noteworthy that 15 of the enriched mRNAs themselves have been shown to localize to dendritic spines, the post-synaptic density, or (in one case) at the post-synaptic membrane of the neuromuscular junction: Ppp1r9b, Dbn1, Myh9, Plec1, Spna2, Spnb2, Actn4, Actn1, Gsn, Nes, Pls3, Utrn, Dst, Myo1b, Shrm [61]–[69].
Gene_expression (expression) of Ppp1r9b in spines
3) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0

General Comments

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