INT167898

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.32
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ppp1r9b) nucleoplasm (Ppp1r9b) plasma membrane (Ppp1r9b)
cytoskeleton (Ppp1r9b) nucleus (Ppp1r9b) cytoplasm (Ppp1r9b)
Ppp1r9b (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 2 98.72 Very High Very High Very High
agonist 8 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypotension 4 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that eliminating spinophilin expression in native tissues leads to an enhanced receptor/G protein coupling efficiency that contributes to sensitization of receptor mediated responses in vivo.
Negative_regulation (eliminating) of Gene_expression (expression) of spinophilin
1) Confidence 0.42 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20430865 Disease Relevance 0.15 Pain Relevance 0.22
Mice lacking spinophilin expression display dramatically enhanced and prolonged hypotensive, bradycardic, and sedative-hypnotic responses to alpha(2)AR stimulation.
Negative_regulation (lacking) of Gene_expression (expression) of spinophilin associated with hypotension
2) Confidence 0.42 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20430865 Disease Relevance 0.17 Pain Relevance 0.27

General Comments

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