INT167926

Context Info Confidence 0.50 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.48 Pain Relevance 0.56

transport (P2rx3) Golgi apparatus (P2rx3)

Anatomy Link Frequency neuronal 1 C8-B4 1 P2rx3 (Mus musculus)

Pain Link Frequency Relevance Heat dorsal root ganglion 4 89.20 Pain 4 75.00 Glutamate 1 60.84 gABA 1 60.04 Neuropathic pain 10 58.40 imagery 6 49.64 neuralgia 2 25.00 antidepressant 35 5.00 Endep 16 5.00 antagonist 6 5.00

Disease Link Frequency Relevance Heat Injury 5 99.44 Sprains And Strains 4 81.16 Ganglion Cysts 4 75.16 Pain 4 75.00 Nervous System Injury 3 75.00 Neuropathic Pain 12 58.40 Myelodysplastic Syndromes 2 5.00 Anaplastic Astrocytoma 1 5.00 Targeted Disruption 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Finally, in C58 mice there was a shift toward smaller P2X3-expressing neuronal profiles after injury, suggesting that a loss of P2X3 mRNA transcript occurred preferentially in medium-sized cells.

Transcription (transcript) of P2X3 in neuronal associated with injury

1) Confidence 0.50 Published 2010 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 20433603 Disease Relevance 1.48 Pain Relevance 0.50

We found significant amounts of P2X3, P2X4, P2X6, and P2X7 transcripts in resting C8-B4 cells with the following relative expression levels: P2X7 > P2X4 > P2X3 > P2X6.

Transcription (transcripts) of P2X3 in C8-B4

2) Confidence 0.13 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2847917 Disease Relevance 0 Pain Relevance 0.06

General Comments

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