INT167938

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.85

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cytosol (Stat5b) signal transduction (Stat5b) nucleus (Stat5b)
DNA binding (Stat5b) cytoplasm (Stat5b) signal transducer activity (Stat5b)
Stat5b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 10 99.74 Very High Very High Very High
Enkephalin 2 98.34 Very High Very High Very High
cytokine 2 78.64 Quite High
Opioid 2 73.24 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[D-Ser(2), Leu(5), Thr(6)]-enkephalin-exposure of HEK293 cells, expressing stably the delta-opioid receptor (delta-OR), leads to receptor-dependent STAT5B tyrosine phosphorylation and transcriptional activation.
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of STAT5B associated with opioid receptor and enkephalin
1) Confidence 0.33 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 20433855 Disease Relevance 0 Pain Relevance 0.42
[D-Ser(2), Leu(5), Thr(6)]-enkephalin-exposure of HEK293 cells, expressing stably the delta-opioid receptor (delta-OR), leads to receptor-dependent STAT5B tyrosine phosphorylation and transcriptional activation.
Positive_regulation (leads) of Phosphorylation (phosphorylation) of STAT5B associated with opioid receptor and enkephalin
2) Confidence 0.33 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 20433855 Disease Relevance 0 Pain Relevance 0.43

General Comments

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