INT16794

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 103
Total Number 120
Disease Relevance 64.87
Pain Relevance 19.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
brain 8
cleavage 5
plaques 5
microglia 3
neuronal 3
App (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 298 100.00 Very High Very High Very High
Abeta 65 100.00 Very High Very High Very High
antagonist 56 100.00 Very High Very High Very High
Eae 45 100.00 Very High Very High Very High
Inflammatory mediators 24 100.00 Very High Very High Very High
narcan 12 100.00 Very High Very High Very High
opiate 6 100.00 Very High Very High Very High
cINOD 541 99.82 Very High Very High Very High
Dopamine 22 99.64 Very High Very High Very High
positron emission tomography 146 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 4622 100.00 Very High Very High Very High
Alzheimer's Dementia 2341 100.00 Very High Very High Very High
INFLAMMATION 1141 100.00 Very High Very High Very High
Watson Syndrome 224 100.00 Very High Very High Very High
Immunization 30 100.00 Very High Very High Very High
Syndrome 410 99.72 Very High Very High Very High
Targeted Disruption 2392 99.68 Very High Very High Very High
Frontotemporal Dementia 48 99.56 Very High Very High Very High
Drug Induced Neurotoxicity 104 99.16 Very High Very High Very High
Generaliased Trisomy 33 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increasing number of proteins that interact with APP or act as trafficking factors are being implicated in the regulation of A?
APP Binding (interact) of
1) Confidence 0.48 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.13 Pain Relevance 0.06
However, while binding of APP by these ligands can affect APP processing, the exact downstream signaling events triggered by such binding remains to be clarified and a bona fide membrane receptor function for APP remains speculative.
APP Binding (binding) of
2) Confidence 0.48 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.20 Pain Relevance 0
Our data suggest that physical interactions between FMRP and APP mRNA underlie translational repression, with mGluR activation rapidly moderating these events.
APP mRNA Binding (interactions) of associated with repression
3) Confidence 0.48 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.16 Pain Relevance 0
Presumably, the loss of FMRP/APP mRNA interaction results in rapid, pulsatile protein expression in dendrites.


APP mRNA Binding (interaction) of in dendrites
4) Confidence 0.48 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.15 Pain Relevance 0
Recent advances in the understanding of the generation of amyloid in Alzheimer's disease has lead to the finding that BRI2 interacts with the Amyloid Precursor Protein (APP), decreasing the efficiency of APP processing to generate A?
Amyloid Precursor Protein Binding (interacts) of associated with alzheimer's dementia and disease
5) Confidence 0.43 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2774945 Disease Relevance 0.84 Pain Relevance 0
Recent advances in the understanding of the generation of amyloid in Alzheimer's disease has lead to the finding that BRI2 interacts with the Amyloid Precursor Protein (APP), decreasing the efficiency of APP processing to generate A?
APP Binding (interacts) of associated with alzheimer's dementia and disease
6) Confidence 0.43 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2774945 Disease Relevance 0.84 Pain Relevance 0
The interaction between the two precursors, APP and BRI2, and possibly between A?
APP Binding (interaction) of
7) Confidence 0.43 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2774945 Disease Relevance 0.84 Pain Relevance 0
Conversely, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
APP Binding (interaction) of
8) Confidence 0.43 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.09 Pain Relevance 0
X-ray structural information of a peptide inhibitor bound to rhizopuspepsin was also incorporated to model the interaction with APP.
APP Binding (interaction) of
9) Confidence 0.43 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0 Pain Relevance 0
Interestingly, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
APP Binding (interaction) of
10) Confidence 0.43 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.08 Pain Relevance 0
This estimate was confirmed by direct comparison of APP levels in nontransgenic and tet-off APP mice using an antibody that recognizes both endogenous APP (and amyloid precursor-like protein 2) and the transgenic protein (monoclonal antibody 22C11; Figure 1D).
APP Binding (recognizes) of associated with targeted disruption and alzheimer's dementia
11) Confidence 0.42 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.54 Pain Relevance 0.04
40 and increased zinc levels in the brain without changing GFAP, SOD1, APP, C100, or NF200 levels to TgC100 mice.
APP Binding (changing) of in brain
12) Confidence 0.37 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.58 Pain Relevance 0.15
The accumulation of neurofilament, APP, tau and ubiquitin epitopes is associated with morphological changes of the neurites.
APP Binding (associated) of in neurites
13) Confidence 0.37 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.37 Pain Relevance 0.07
It allows the internalization of several ligands such as ApoE, APP (with the Kunitz inhibitor) and ?
APP Binding (ligands) of
14) Confidence 0.37 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.82 Pain Relevance 0.09
One study showed that the ectodomain of Nicastrin binds to APP and Notch and can recruit them into the ?
APP Binding (binds) of in Notch
15) Confidence 0.37 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.07 Pain Relevance 0
deposition [9]; and prolonged activation of extrasynaptic NMDA receptor in neurons can shift APP expression from APP695 to KPI-containing APP isoforms, accompanied with increased production of A?
APP Binding (containing) of in neurons associated with nmda receptor
16) Confidence 0.37 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.54 Pain Relevance 0.08
There are reports showing that the protein and mRNA levels of KPI-containing APP isoforms are elevated in AD brain and associated with increased A?
APP Binding (associated) of in brain associated with disease
17) Confidence 0.37 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.63 Pain Relevance 0.08
However, as the intracellular domain of APP, one important function of AICD is to facilitate the interaction of APP with various cytosolic factors that regulate APP's intracellular trafficking and/or signal transduction function.
APP Binding (interaction) of
18) Confidence 0.37 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.22 Pain Relevance 0
APP is expressed in all tissues and could undergo cleavage by either ?
APP Binding (undergo) of in cleavage
19) Confidence 0.37 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.12 Pain Relevance 0
Alternative methods for plaque imaging are under scrutinization in APP(xPS1) mice (e.g., Near InfraRed Fluorescence (NIRF) in vivo imaging of new compounds that bind to plaques [89] or Diffraction Enhanced Imaging (DEI), a phase contrast X-ray imaging technique that provides high soft tissue contrast which allows A?
APP Binding (scrutinization) of in plaques associated with imagery
20) Confidence 0.37 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952791 Disease Relevance 0.62 Pain Relevance 0.49

General Comments

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