INT167952

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.96
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (S1pr1) plasma membrane (S1pr1) signal transducer activity (S1pr1)
Anatomy Link Frequency
CSF 2
lymphocyte 1
S1pr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 91 99.60 Very High Very High Very High
Multiple sclerosis 18 99.40 Very High Very High Very High
rheumatoid arthritis 130 97.72 Very High Very High Very High
Arthritis 128 94.68 High High
Inflammatory response 9 93.80 High High
headache 2 89.72 High High
intrathecal 2 75.00 Quite High
chemokine 6 65.20 Quite High
methotrexate 8 22.56 Low Low
cytokine 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 42 99.60 Very High Very High Very High
Demyelinating Disease 20 99.40 Very High Very High Very High
Rheumatoid Arthritis 130 97.72 Very High Very High Very High
Apoptosis 105 95.96 Very High Very High Very High
Arthritis 124 95.20 Very High Very High Very High
Paralysis 2 91.44 High High
Headache 2 89.72 High High
Carcinoma 3 87.00 High High
Bordatella Infection 2 61.36 Quite High
Hyperplasia 6 53.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies suggested that it was SPL, rather than S1P, that regulated mitogenesis in this cell line.
Regulation (regulated) of S1P
1) Confidence 0.26 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.42 Pain Relevance 0.15
We hypothesize that during the course of multiple sclerosis (MS) development, chronic inflammation will result in the alteration of S1P levels in blood and cerebrospinal fluid (CSF).
Regulation (alteration) of S1P in CSF associated with multiple sclerosis and inflammation
2) Confidence 0.25 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20434523 Disease Relevance 0.83 Pain Relevance 0.46
However, S1P concentrations in CSF of the MS group were significantly higher (p<0.01) compared to the control group (2.2+/-2.7 versus 0.69+/-1.1 nM).
Regulation (concentrations) of S1P in CSF associated with multiple sclerosis
3) Confidence 0.25 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20434523 Disease Relevance 1.09 Pain Relevance 0.58
What is the current evidence that altering the activity of S1P would provide significant and beneficial effects by restricting some of the pathophysiologic events that contribute to inflammatory arthritis?
Regulation (altering) of S1P associated with inflammation and arthritis
4) Confidence 0.16 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.50 Pain Relevance 0.19
These observations combined with the role of S1P in lymphocyte egress underscore the importance of lysophospholipids in lymphocyte trafficking and assign LPA and S1P to distinct steps, homing and egress respectively.
Regulation (importance) of S1P in lymphocyte
5) Confidence 0.11 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.12 Pain Relevance 0.03

General Comments

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