INT16800

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Context Info
Confidence 0.62
First Reported 1991
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.01
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gap43)
Anatomy Link Frequency
neural 2
brain 1
Gap43 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 2 100.00 Very High Very High Very High
Central nervous system 8 91.56 High High
anesthesia 4 77.12 Quite High
antagonist 2 64.64 Quite High
tetrodotoxin 2 55.80 Quite High
Hippocampus 4 48.56 Quite Low
Thalamus 2 43.28 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 2 98.64 Very High Very High Very High
Brain Injury 6 93.40 High High
Injury 8 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Presynaptic mechanism of action of 4-aminopyridine: changes in intracellular free Ca2+ concentration and its relationship to B-50 (GAP-43) phosphorylation.
Phosphorylation (phosphorylation) of GAP-43
1) Confidence 0.62 Published 1991 Journal J. Neurochem. Section Title Doc Link 1851203 Disease Relevance 0 Pain Relevance 0.14
Recently we have shown that 4-aminopyridine (4-AP), a drug known to enhance transmitter release, stimulates the phosphorylation of the protein kinase C substrate B-50 (GAP-43) in rat brain synaptosomes and that this effect is dependent on the presence of extracellular Ca2+.
Phosphorylation (phosphorylation) of GAP-43 in brain associated with kinase c
2) Confidence 0.62 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1851203 Disease Relevance 0 Pain Relevance 0.05
The regional expression of proteins associated with axonal elongation, such as microtubule-associated protein 1B (MAP1B), its phosphorylated isoform (MAP1B-P), growth-associated protein 43 (GAP-43), and polysialylated neural cell-adhesion molecule (PSA-NCAM), was examined using immunohistochemistry from 24 hours to 2 months following lateral fluid percussion brain injury of moderate severity (2.4-2.6 atmospheres) in anesthetized rats.
Phosphorylation (phosphorylated) of GAP-43 in neural associated with brain injury and adhesions
3) Confidence 0.56 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10906717 Disease Relevance 0.50 Pain Relevance 0.24
The regional expression of proteins associated with axonal elongation, such as microtubule-associated protein 1B (MAP1B), its phosphorylated isoform (MAP1B-P), growth-associated protein 43 (GAP-43), and polysialylated neural cell-adhesion molecule (PSA-NCAM), was examined using immunohistochemistry from 24 hours to 2 months following lateral fluid percussion brain injury of moderate severity (2.4-2.6 atmospheres) in anesthetized rats.
Phosphorylation (phosphorylated) of growth-associated protein 43 in neural associated with brain injury and adhesions
4) Confidence 0.49 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 10906717 Disease Relevance 0.50 Pain Relevance 0.24

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