INT168003

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Context Info
Confidence 0.80
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 12.52
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf2) signal transduction (Fgf2) extracellular space (Fgf2)
extracellular region (Fgf2) nucleus (Fgf2) embryo development (Fgf2)
Anatomy Link Frequency
fibroblast 3
brain 2
astrocyte 2
hepatocyte 1
platelet 1
Fgf2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 129 100.00 Very High Very High Very High
Spinal cord 444 99.32 Very High Very High Very High
rheumatoid arthritis 100 99.26 Very High Very High Very High
Central nervous system 117 96.12 Very High Very High Very High
medulla 135 95.36 Very High Very High Very High
Inflammation 148 92.80 High High
cerebral cortex 31 90.64 High High
Arthritis 47 89.56 High High
Pyramidal cell 1 77.76 Quite High
Peripheral nervous system 19 73.36 Quite High
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 9 99.64 Very High Very High Very High
Spinal Cord Injury 108 99.32 Very High Very High Very High
Rheumatoid Arthritis 101 99.26 Very High Very High Very High
Cancer 111 99.08 Very High Very High Very High
Wound Healing 43 99.04 Very High Very High Very High
Radiation Sickness 1 96.72 Very High Very High Very High
Multiple Myeloma 24 96.64 Very High Very High Very High
Apoptosis 161 96.40 Very High Very High Very High
Diabetic Foot Ulcer 1 94.80 High High
Myopia 13 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Colocalization of FGF-2 and GFAP was obvious in all these cells.
Localization (Colocalization) of FGF-2
1) Confidence 0.80 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.23 Pain Relevance 0.19
The observation of FGF-2 colocalization with GFAP after spinal cord injury supports the idea that FGF-2 may stimulate astrocytic activation in the brain as predicted by previous studies in vitro (Morrison and De Villis, 1981).
Localization (colocalization) of FGF-2 in brain associated with spinal cord
2) Confidence 0.80 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.17 Pain Relevance 0.16
To further investigate the cellular mechanisms underlying FGF-2 restorative actions and to analyze the changes within astroglial cells, we studied the localization of GFAP and FGF-2 in adult intact and injured Pleurodeles CNS.
Localization (localization) of FGF-2
3) Confidence 0.80 Published 2010 Journal Frontiers in Cellular Neuroscience Section Abstract Doc Link PMC2990542 Disease Relevance 0.45 Pain Relevance 0.16
Alternatively, this may be due to FGF-2 release from injured cells into the extracellular matrix (D'Amore, 1990), followed by binding to FGFR1-bearing astrocytes.
Localization (release) of FGF-2 in extracellular matrix
4) Confidence 0.80 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.08 Pain Relevance 0.12
In order to better understand the activation process occurring in astrocytes, we measured the colocalization between FGF-2 and GFAP after lesion by assessing FGF-2 intensity in both types of cells in each region of the CNS.
Localization (colocalization) of FGF-2 in astrocytes associated with central nervous system
5) Confidence 0.80 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0 Pain Relevance 0.14
The selected subline secreted more proangiogenic factors VEGF and bFGF in vitro compared to the parental cell line suggesting that these tumors are highly vascular.
Localization (secreted) of bFGF associated with cancer
6) Confidence 0.77 Published 2010 Journal Clin. Exp. Metastasis Section Abstract Doc Link 20443133 Disease Relevance 1.21 Pain Relevance 0.06
Our studies demonstrated that FGF-2 is localized all along the neural axis, starting by cells lining the 4th ventricle in brain stem regions and gradually decreasing with the onset of differentiation in the ependymal cells of the regenerating cord.
Localization (localized) of FGF-2 in ependymal cells
7) Confidence 0.74 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.23 Pain Relevance 0.18
weeks post-op in FGF-2-GFAP colocalization was obvious in both extremes of the system, FGF-2 intensity reached a level 25% more colocalization in SC3 than in BS (Table 3).
Localization (colocalization) of FGF-2-GFAP associated with medulla
8) Confidence 0.74 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.10 Pain Relevance 0.26
The colocalization of FGF-2 and GFAP in the same cells (shown in orange, Figures 1A, B) suggests that the neuroglial cells lining the fourth ventricle are a major source of FGF-2 starting 1 week after spinal cord lesion.
Localization (colocalization) of FGF-2 in neuroglial cells associated with spinal cord
9) Confidence 0.70 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.08 Pain Relevance 0.12
This is known as the mechanisms of FGF-2 “export
Localization (export) of FGF-2
10) Confidence 0.70 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.09 Pain Relevance 0.13
Simultaneous removal of EGF and FGF-2 on laminin results in astrocyte differentiation (unpublished data).
Localization (removal) of FGF-2 in astrocyte
11) Confidence 0.42 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0.51 Pain Relevance 0
geo lineage selection with G418 [31,37] for 48 h to enrich for neural precursors, then dissociated and cultured in the presence of FGF-2 and EGF without serum.
Localization (presence) of FGF-2 in neural
12) Confidence 0.42 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1184591 Disease Relevance 0 Pain Relevance 0
In any case our cultures do not sustain conditions for the genesis of neurons from astroglia (even in the presence of EGF/FGF2) without forced expression of neurogenic fate determinants.
Localization (presence) of FGF2 in neurons
13) Confidence 0.41 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0 Pain Relevance 0.08
Patients with early RA had significantly elevated synovial levels of IL-2, IL-4, IL-13, IL-17, EGF and bFGF when compared with patients with established RA (Figs 1 and 2, and Table 2).
Localization (levels) of bFGF associated with rheumatoid arthritis
14) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 2.22 Pain Relevance 0.94
The zinc-finger protein Egr-1 is located in the nucleus [32-34] and has numerous target genes [35], among which are PDGF-A [36] and PDGF-B [37], bFGF [38] and TGF-?
Localization (located) of bFGF in nucleus
15) Confidence 0.36 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.19 Pain Relevance 0.03
Various types of polymeric materials have been used for controlled release of bFGF and VEGF, including alginate hydrogels, PLG microspheres, and porous PLG scaffolds (22,23).
Localization (release) of bFGF
16) Confidence 0.35 Published 2009 Journal Pharm Res Section Body Doc Link PMC2812420 Disease Relevance 0.09 Pain Relevance 0
cells/mL were cultured in serum-free complete growth medium 1 (GM1) in the presence of epidermal growth factor and basic fibroblast growth factor (both 10?
Localization (presence) of basic fibroblast growth factor in fibroblast
17) Confidence 0.34 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2821778 Disease Relevance 0 Pain Relevance 0.03
Although the grade of leukocyte infiltration was similar among the genotypes by the end of the study, higher levels of both, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) were secreted by TSP1?
Localization (secreted) of bFGF in fibroblast
18) Confidence 0.34 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.17 Pain Relevance 0.12
Although the grade of leukocyte infiltration was similar among the genotypes by the end of the study, higher levels of both, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) were secreted by TSP1?
Localization (secreted) of basic fibroblast growth factor in fibroblast
19) Confidence 0.34 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.23 Pain Relevance 0.12
Although LeTx treatment does decrease the release of a number of angio-proliferative factors, including basic fibroblast growth factor (bFGF), IL-8, and VEGF from tumor cells [11] it appears that the primary effects of LeTx are mediated by a non-tumor compartment, likely endothelial cells [11], [12], [13].
Localization (release) of bFGF in endothelial cells associated with cancer
20) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737623 Disease Relevance 1.00 Pain Relevance 0.08

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