INT168010

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 3.03
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBG2) transport (HBG2)
Anatomy Link Frequency
erythrocytes 2
Asap1 (Mus musculus)
HBG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 24 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 9 99.44 Very High Very High Very High
Toxicity 6 96.24 Very High Very High Very High
Methemoglobinemia 15 96.04 Very High Very High Very High
Hemolysis 3 80.12 Quite High
Overdose 6 78.16 Quite High
Hepatotoxicity 3 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAP also induced more methemoglobin in erythrocytes from Nat1/Nat2 knockout mice than wildtype (WT) mouse erythrocytes (P < 0.05), but less than in dog and cat erythrocytes (P < 0.01).
PAP Positive_regulation (induced) of methemoglobin in erythrocytes associated with targeted disruption
1) Confidence 0.01 Published 2009 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 20444014 Disease Relevance 1.02 Pain Relevance 0.61
APAP caused no hematotoxicity while PAP induced more methemoglobin in NAT1/NAT2 knockout mice than in WT mice (P < 0.05).
PAP Positive_regulation (induced) of methemoglobin associated with targeted disruption and paracetamol
2) Confidence 0.01 Published 2009 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 20444014 Disease Relevance 1.00 Pain Relevance 0.61
Only PAP induced methemoglobin and it induced more methemoglobin formation in dog and cat than rat and mouse erythrocytes.
PAP Positive_regulation (induced) of methemoglobin in erythrocytes
3) Confidence 0.01 Published 2009 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 20444014 Disease Relevance 1.00 Pain Relevance 0.60

General Comments

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