INT168065

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.55
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Anatomy Link Frequency
neuronal 2
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 82 98.54 Very High Very High Very High
Hippocampus 9 88.56 High High
Multiple sclerosis 62 88.04 High High
Demyelination 12 87.12 High High
Inflammation 20 86.52 High High
tolerance 9 84.04 Quite High
agonist 14 72.40 Quite High
Intracerebroventricular 1 59.36 Quite High
Spinal cord 2 41.00 Quite Low
Potency 8 40.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 148 99.56 Very High Very High Very High
Neurodegenerative Disease 34 97.16 Very High Very High Very High
Lifespan 58 95.80 Very High Very High Very High
Stress 46 94.92 High High
Disease 97 93.16 High High
Death 101 92.24 High High
Aging 52 90.04 High High
Multiple Sclerosis 35 89.60 High High
Demyelinating Disease 84 88.04 High High
Cancer 43 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lysine acetylation is necessary
                       for the interaction between SIRT1 and other sirtuins their targets
                       before deacetylation can
                       occur.  
SIRT1 Binding (interaction) of
1) Confidence 0.47 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC2837205 Disease Relevance 0 Pain Relevance 0
activity will
                       be also affected by this cycle through its interaction with SIRT1. 
SIRT1 Binding (interaction) of
2) Confidence 0.47 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC2837205 Disease Relevance 0.06 Pain Relevance 0
The effect of EA on SIRT1 gene expression and protein levels was investigated in view of SIRT1's association with metabolic activity and its critical role in insulin sensitivity.
SIRT1 Binding (association) of associated with electroacupuncture
3) Confidence 0.35 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.14 Pain Relevance 0.45
in neuronal metabolism (St-Pierre et al 2006) and the link between resveratrol, SIRT-1, and PGC-1?
SIRT-1 Binding (link) of in neuronal
4) Confidence 0.34 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.98 Pain Relevance 0.08
Several recent reports presented evidence that SIRT-1 interacts directly and deacetylates the metabolic regulator and transcriptional coactivator, peroxisome proliferator-activated receptor-?
SIRT-1 Binding (interacts) of
5) Confidence 0.33 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.32 Pain Relevance 0.04
All of these effects are potentially mediated by the pleiotropic interactions of resveratrol with different enzyme targets including COX-1 (cyclo-oxygenase-1) and COX-2, NAD+-dependent histone deacetylase SIRT1 (sirtuin 1) and QR2 (quinone reductase 2).
SIRT1 Binding (interactions) of
6) Confidence 0.29 Published 2010 Journal Biochem. J. Section Abstract Doc Link 20450491 Disease Relevance 0.18 Pain Relevance 0
Mutant forms of SIRT1 lacking deacetylase activity are completely neuroprotective
SIRT1 Binding (activity) of
7) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.25 Pain Relevance 0.04
Association between SIRT1 and p53, p65, c-jun and E2F1, all of which are involved in regulating neuronal apoptosis, has previously been reported (reviewed in [1]; [55], [64]–[66]).
SIRT1 Binding (Association) of in neuronal associated with neurodegenerative disease
8) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.38 Pain Relevance 0
Further effort will be necessary to define what this mechanism is but one possibility is that it involves interactions between SIRT1 and other apoptosis-regulatory proteins.
SIRT1 Binding (interactions) of associated with apoptosis
9) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.33 Pain Relevance 0.03
Previous studies have suggested that the N-terminus region of SIRT1 is involved in interaction with other proteins and contains two potential phosphorylation sites (Ser27 and Ser47; [28], [29]).
SIRT1 Binding (interaction) of
10) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.29 Pain Relevance 0
Indeed, resveratrol binds to and activates the deacetylase activity of several sirtuin members, including the mammalian ortholog, SIRT1, by lowering the Michaelis constants of these enzymes [37].
SIRT1 Binding (binds) of
11) Confidence 0.22 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604890 Disease Relevance 0.73 Pain Relevance 0.08
by increasing NAD concentrations is expected to activate SIRT-1, which has a
SIRT-1 Binding (has) of
12) Confidence 0.11 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.88 Pain Relevance 0.31
The main effect of Information category was highly significant, F (4.4; 84.1) = 8.80, p < .01, as was Information category × Case interaction, F (9.1; 172.2) = 11.80, p < .01.
Information Binding (interaction) of
13) Confidence 0.02 Published 2004 Journal BMC Med Inform Decis Mak Section Body Doc Link PMC539306 Disease Relevance 0 Pain Relevance 0

General Comments

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