INT168068

Context Info Confidence 0.46 First Reported 2009 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 3 Total Number 9 Disease Relevance 8.82 Pain Relevance 1.77

Anatomy Link Frequency Poly 2 lung 1 Mat1a (Mus musculus)

Pain Link Frequency Relevance Heat agonist 66 99.92 Paracetamol 19 99.36 Inflammation 96 96.92 Hippocampus 4 65.68 isoflurane 18 16.64 cytokine 36 5.00 anesthesia 8 5.00 Inflammatory response 6 5.00 chemokine 6 5.00 adenocard 4 5.00

Disease Link Frequency Relevance Heat Coronavirus Infection 168 99.26 Aging 38 99.20 Severe Acute Respiratory Syndrome 228 99.18 Toxicity 5 99.16 Sprains And Strains 30 99.02 Influenza Virus Infection 48 98.64 Disease 220 98.12 INFLAMMATION 102 96.92 Infection 258 96.20 Hypersensitivity 6 92.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Studies further examined MAT expression and activity in response to APAP toxicity.

Spec (examined) Positive_regulation (activity) of MAT associated with toxicity and paracetamol

1) Confidence 0.46 Published 2010 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 20450926 Disease Relevance 0.51 Pain Relevance 1.12

In addition they measured the synthesis of AdoMet by adenosyl transferase and AdoMet utilization by COMT, and concluded that the decrease in AdoMet levels was a consequence of increased utilization during aging.

Positive_regulation (increased) of AdoMet associated with aging

2) Confidence 0.35 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.64 Pain Relevance 0.03

This could have explained the high-AdoMet levels; however, the AdoMet levels in the 8-month-old APP/PS1 mice in our study, should have been increased compared to 8-month-old wild types, and that was not the case.

Positive_regulation (increased) of AdoMet

3) Confidence 0.35 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.46 Pain Relevance 0.03

Treatment with TLR agonists to activate AMs and rDCs or transfer of activated BMDCs also prevents a lethal outcome.

Positive_regulation (activate) of AMs associated with agonist

4) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.67 Pain Relevance 0.10

The inhibitory effects of AM can also be nullified if mice or AMs are pretreated with poly I:C, which directly activate AMs and rDCs through toll-like receptors 3 (TLR3).

Positive_regulation (activate) of AMs in poly

5) Confidence 0.22 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2762542 Disease Relevance 1.18 Pain Relevance 0

Poly I:C, which activated AMs and rDC in vivo (Fig. 5 C and S7) and in vitro (Fig. 6 A), protected animals from lethal MA15 infection.

Positive_regulation (activated) of AMs in Poly associated with infection

6) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.74 Pain Relevance 0.17

Second, activation of AMs and rDCs in situ via treatment with TLR agonists also circumvented the anti-inflammatory state of the lung.

Positive_regulation (activation) of AMs in lung associated with inflammation and agonist

7) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.00 Pain Relevance 0.21

In conclusion, we have shown that lethal disease in mice infected with a mouse-adapted strain of SARS-CoV (MA15) is correlated with a lack of activation of AMs and rDCs.

Positive_regulation (activation) of AMs associated with coronavirus infection, severe acute respiratory syndrome, sprains and strains and disease

8) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 1.90 Pain Relevance 0.09

This transfer was successful because inhibitory AMs cannot reverse prior rDC activation (Fig. 7 A).

Neg (cannot) Positive_regulation (activation) of AMs

9) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.71 Pain Relevance 0.03

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