INT168068
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Studies further examined MAT expression and activity in response to APAP toxicity. | |||||||||||||||
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In addition they measured the synthesis of AdoMet by adenosyl transferase and AdoMet utilization by COMT, and concluded that the decrease in AdoMet levels was a consequence of increased utilization during aging. | |||||||||||||||
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This could have explained the high-AdoMet levels; however, the AdoMet levels in the 8-month-old APP/PS1 mice in our study, should have been increased compared to 8-month-old wild types, and that was not the case. | |||||||||||||||
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Treatment with TLR agonists to activate AMs and rDCs or transfer of activated BMDCs also prevents a lethal outcome. | |||||||||||||||
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The inhibitory effects of AM can also be nullified if mice or AMs are pretreated with poly I:C, which directly activate AMs and rDCs through toll-like receptors 3 (TLR3). | |||||||||||||||
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Poly I:C, which activated AMs and rDC in vivo (Fig. 5 C and S7) and in vitro (Fig. 6 A), protected animals from lethal MA15 infection. | |||||||||||||||
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Second, activation of AMs and rDCs in situ via treatment with TLR agonists also circumvented the anti-inflammatory state of the lung. | |||||||||||||||
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In conclusion, we have shown that lethal disease in mice infected with a mouse-adapted strain of SARS-CoV (MA15) is correlated with a lack of activation of AMs and rDCs. | |||||||||||||||
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This transfer was successful because inhibitory AMs cannot reverse prior rDC activation (Fig. 7 A). | |||||||||||||||
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