INT16808

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Context Info
Confidence 0.00
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 7.18
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Scd1) endoplasmic reticulum (Scd1) lipid metabolic process (Scd1)
Anatomy Link Frequency
brush 1
Scd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 3 99.60 Very High Very High Very High
Enkephalin 5 94.24 High High
Opioid 2 76.16 Quite High
Delta opioid receptors 1 75.00 Quite High
Bioavailability 6 31.96 Quite Low
narcan 2 25.00 Low Low
opioid receptor 1 25.00 Low Low
ischemia 3 9.96 Low Low
cva 2 8.40 Low Low
sodium channel 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 186 100.00 Very High Very High Very High
Sickle Cell Anemia 81 100.00 Very High Very High Very High
Thrombophilia 18 99.98 Very High Very High Very High
Thalassemia 75 99.80 Very High Very High Very High
Right Ventricular Dysfunction 3 97.56 Very High Very High Very High
Hemolysis 48 96.04 Very High Very High Very High
Increased Venous Pressure Under Development 10 92.60 High High
Vasculitis 3 89.00 High High
Stress 8 86.12 High High
Natriuresis 6 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A monoclonal antibody (mAb), KA8 that interacts with the kappa-opioid receptor binding site was generated.
mAb Binding (interacts) of associated with kappa opioid receptor
1) Confidence 0.00 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1851205 Disease Relevance 0 Pain Relevance 0.23
Immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis studies of radiolabeled brush border proteins indicate that mAb 85A2 binds specifically an antigen with an apparent molecular weight of 90 kilodaltons, corresponding to published values for enkephalinase.
mAb Binding (binds) of in brush
2) Confidence 0.00 Published 1988 Journal Lab. Invest. Section Abstract Doc Link 3276960 Disease Relevance 0 Pain Relevance 0.09
This latter possibility is further supported by the increase in stearoyl-CoA desaturase index in PiT1neo/neo mice.
stearoyl-CoA desaturase Binding (index) of
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.05 Pain Relevance 0
Finally, the hypercoagulable state associated with SCD and thalassemia has been shown to contribute to the development of PH through a series of recent experiments.
SCD Binding (associated) of associated with sickle cell anemia, thrombophilia, hypertension and thalassemia
4) Confidence 0.13 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.33 Pain Relevance 0
Multiple prospective screening studies have found roughly a third of adult patients with SCD have PH as defined by a TRV of ?
SCD Binding (found) of associated with sickle cell anemia and hypertension
5) Confidence 0.10 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.25 Pain Relevance 0
It has more recently been validated as a biomarker for PH in SCD.
SCD Binding (biomarker) of associated with sickle cell anemia and hypertension
6) Confidence 0.10 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.55 Pain Relevance 0
Secondly, to confirm the binding of the Ab to the free hapten, competitive inhibition ELISA (CIEA) is performed: a fixed and limiting amount of Ab is pre-incubated with increasing concentrations of the free targeted hapten.
Ab Binding (binding) of
7) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0 Pain Relevance 0

General Comments

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