INT16814

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 74
Total Number 76
Disease Relevance 33.72
Pain Relevance 28.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (COX5A) small molecule metabolic process (COX5A)
Anatomy Link Frequency
colon 2
muscle 2
platelet 2
muscle fiber 2
blood 2
COX5A (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 43 100.00 Very High Very High Very High
cINOD 259 99.98 Very High Very High Very High
licofelone 18 99.88 Very High Very High Very High
tetrodotoxin 1 99.82 Very High Very High Very High
Analgesic 29 99.76 Very High Very High Very High
Inflammation 74 99.56 Very High Very High Very High
aspirin 91 99.40 Very High Very High Very High
rheumatoid arthritis 22 99.28 Very High Very High Very High
Acute pain 10 98.44 Very High Very High Very High
analgesia 5 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Colon Cancer 27 99.92 Very High Very High Very High
INFLAMMATION 147 99.68 Very High Very High Very High
Asthma 9 99.44 Very High Very High Very High
Death 8 99.44 Very High Very High Very High
Rheumatoid Arthritis 22 99.28 Very High Very High Very High
Apoptosis 38 99.20 Very High Very High Very High
Asphyxia 1 99.00 Very High Very High Very High
Anaphylaxis 13 98.94 Very High Very High Very High
Alzheimer's Dementia 1 98.90 Very High Very High Very High
Inclusion Body Myositis 7 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enzyme histochemistry revealed partial deficiency of cytochrome c oxidase (COX) with scattered non-reactive fibers among a majority of COX-positive fibers whereas biochemical analysis of muscle homogenates resulted in no corresponding defect of mitochondrial enzymes.
Spec (partial) Negative_regulation (deficiency) of COX in muscle
1) Confidence 0.57 Published 1991 Journal Pathol. Res. Pract. Section Abstract Doc Link 1851299 Disease Relevance 0.58 Pain Relevance 0.20
These approaches include: apoptosis inhibitors; inhibitors of APP processing (prolyl endopeptidase (EC 3.4.21.26) inhibitors, gamma-secretase inhibitors, and inhibitors of amyloid aggregation); and, prostaglandin formation (COX-2 and COX/5-LO inhibitors).
Negative_regulation (inhibitors) of COX associated with alzheimer's dementia and apoptosis
2) Confidence 0.57 Published 1998 Journal IDrugs Section Abstract Doc Link 18465621 Disease Relevance 0.84 Pain Relevance 0.08
Today's challenge is to translate this information into clinical trials to define what role, if any, COX inhibition might play in the prevention of these malignancies.
Negative_regulation (inhibition) of COX
3) Confidence 0.57 Published 2001 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 11764539 Disease Relevance 0.15 Pain Relevance 0.12
Modifications were carried out on this scaffold to obtain potent inhibitors of the COX enzymes.
Negative_regulation (inhibitors) of COX
4) Confidence 0.57 Published 2002 Journal Eur J Med Chem Section Abstract Doc Link 11858847 Disease Relevance 0.09 Pain Relevance 0.32
OBJECTIVE: We studied whether dipyrone, which has recently been reported to inhibit COX isoforms by a mechanism different from conventional non-steroidal anti-inflammatory drugs (NSAIDs), also interferes with the antiplatelet effect of aspirin.
Negative_regulation (inhibit) of COX
5) Confidence 0.57 Published 2008 Journal J. Thromb. Haemost. Section Body Doc Link 17944992 Disease Relevance 0 Pain Relevance 0
Inhibition of the cyclooxygenase (COX)-2 enzyme has been shown previously to reduce pain and inflammation.
Negative_regulation (Inhibition) of COX associated with pain and inflammation
6) Confidence 0.57 Published 2002 Journal Am J Ther Section Abstract Doc Link 11897923 Disease Relevance 0.57 Pain Relevance 0.84
Nonsteroidal anti-inflammatory drugs (NSAIDs) are nonselective inhibitors of cyclooxygenase (COX) isoforms COX-1 and COX-2.
Negative_regulation (inhibitors) of COX associated with inflammation and cinod
7) Confidence 0.57 Published 2002 Journal Am. J. Cardiol. Section Abstract Doc Link 11909555 Disease Relevance 0.60 Pain Relevance 0.81
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX enzymes and induce apoptosis in colorectal cancer cell lines, which may contribute to their antitumor effects.
Negative_regulation (inhibit) of COX associated with inflammation, colon cancer, cinod and apoptosis
8) Confidence 0.57 Published 2002 Journal Cancer Res. Section Abstract Doc Link 12414664 Disease Relevance 1.09 Pain Relevance 0.20
For more than a century, inhibition of prostaglandin biosynthesis via inhibition of the fatty acid cyclooxygenase (COX) has been achieved by non-steroidal anti-inflammatory drugs (NSAIDs), which targets both COX-1 and COX-2 and as such could be responsible for causing gastrointestinal (GI) toxicity.
Negative_regulation (inhibition) of COX associated with toxicity, inflammation and cinod
9) Confidence 0.57 Published 2007 Journal Mini Rev Med Chem Section Abstract Doc Link 17584158 Disease Relevance 0.45 Pain Relevance 0.23
The classical NSAIDs display their anti-inflammatory action mainly through inhibition of COX and one of their main drawbacks is the curtailed production of gastroprotective prostaglandins (PGs) being associated with the concurrent increased production of the gastro-damaging and bronchoconstrictive leukotrienes (LTs).
Negative_regulation (inhibition) of COX associated with inflammation and cinod
10) Confidence 0.57 Published 2007 Journal Curr Top Med Chem Section Abstract Doc Link 17305569 Disease Relevance 0.44 Pain Relevance 0.57
Histochemical examination of muscle biopsy specimens revealed reduced COX activity in the majority of the muscle fibers (approximately 90%) and frequent ragged red fibers.
Negative_regulation (reduced) of COX in muscle fibers
11) Confidence 0.57 Published 2005 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 15751226 Disease Relevance 0.62 Pain Relevance 0.10
Inhibition of both COX isozymes is needed to achieve effective analgesia for this type of musculoskeletal pain.
Negative_regulation (Inhibition) of COX associated with pain and analgesia
12) Confidence 0.57 Published 2004 Journal Pain Section Abstract Doc Link 15327804 Disease Relevance 0.55 Pain Relevance 0.89
Consequently, the suppression of spinal cyclooxygenase (COX) and PG formation may contribute to the analgesic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in pain following surgery.
Negative_regulation (suppression) of COX in spinal associated with pain, inflammation, analgesic and cinod
13) Confidence 0.57 Published 2004 Journal Chest Section Abstract Doc Link 15078741 Disease Relevance 0.37 Pain Relevance 0.74
Licofelone, a competitive inhibitor of 5-lipoxygenase, cyclooxygenase (COX)-1 and COX-2, is currently in clinical development for the treatment of osteoarthritis (OA).
Negative_regulation (inhibitor) of COX associated with licofelone and osteoarthritis
14) Confidence 0.57 Published 2004 Journal Rheumatology (Oxford) Section Abstract Doc Link 14752172 Disease Relevance 0.42 Pain Relevance 0.69
RESULTS: Although the precise anticancer actions of NSAIDs are not fully explained, they probably involve inhibition of cyclooxygenase (COX), which is the rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins.
Negative_regulation (inhibition) of COX
15) Confidence 0.57 Published 2003 Journal Scand. J. Gastroenterol. Suppl. Section Body Doc Link 14743889 Disease Relevance 0.18 Pain Relevance 0
A new strategy for anti-inflammatory drug therapy is using a dual inhibitor of COX and lipooxygenase (LOX).
Negative_regulation (inhibitor) of COX associated with inflammation
16) Confidence 0.57 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18760329 Disease Relevance 0.64 Pain Relevance 0.25
Non-selective NSAID that inhibit both COX isoforms are difficult to use for long-term regimens.
Negative_regulation (inhibit) of COX associated with cinod
17) Confidence 0.57 Published 2001 Journal Presse Med Section Abstract Doc Link 11307498 Disease Relevance 0.34 Pain Relevance 0.37
Inhibition of platelet cyclooxygenase (COX)-1 is involved in aspirin cardioprotection observed in clinical trials, but, in some patients, aspirin is unable to protect from thrombotic complications.
Negative_regulation (Inhibition) of COX in platelet associated with aspirin
18) Confidence 0.57 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592549 Disease Relevance 0.14 Pain Relevance 0.21
Both the beneficial and side effects of NSAIDs are, therefore, through their inhibition of COX enzymes.
Negative_regulation (inhibition) of COX associated with cinod
19) Confidence 0.57 Published 2009 Journal Expert Opin Drug Saf Section Abstract Doc Link 19832117 Disease Relevance 0.36 Pain Relevance 0.43
Their therapeutic effects depend on blockade of prostaglandin synthesis through enzyme cyclooxygenase (COX) inhibition.
Negative_regulation (inhibition) of COX
20) Confidence 0.57 Published 2001 Journal Pol. Merkur. Lekarski Section Abstract Doc Link 11503270 Disease Relevance 0.18 Pain Relevance 0.38

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