INT168151

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Context Info
Confidence 0.76
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 17
Disease Relevance 5.58
Pain Relevance 4.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sgk1) endoplasmic reticulum (Sgk1) plasma membrane (Sgk1)
nucleus (Sgk1) kinase activity (Sgk1) response to stress (Sgk1)
Anatomy Link Frequency
neuronal 2
neurons 2
spines 2
brain 1
Sgk1 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 368 99.54 Very High Very High Very High
Morphine 661 98.80 Very High Very High Very High
Locus ceruleus 3 98.60 Very High Very High Very High
Central nervous system 27 98.24 Very High Very High Very High
antagonist 82 93.08 High High
withdrawal 27 92.84 High High
Nucleus accumbens 28 86.12 High High
Hippocampus 9 86.12 High High
Opioid 140 78.16 Quite High
drug abuse 3 76.64 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 205 99.08 Very High Very High Very High
Sprains And Strains 246 97.84 Very High Very High Very High
Breast Cancer 35 96.60 Very High Very High Very High
Apoptosis 212 96.28 Very High Very High Very High
Cancer 215 81.48 Quite High
Hypersensitivity 36 80.08 Quite High
Drug Dependence 60 76.64 Quite High
Lymphatic System Cancer 10 75.68 Quite High
Skin Cancer 13 74.64 Quite High
Metastasis 5 71.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, Sgk1 expression changes might be a compensatory effect to the loss of the protein.
Gene_expression (expression) of Sgk1
1) Confidence 0.76 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.39
Furthermore, in situ hybridization was used to analyze the brain distribution of drug-induced changes in Sgk1 and Tsc22d3 expression.
Gene_expression (expression) of Sgk1 in brain
2) Confidence 0.76 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.44
We also showed that knockdown of the drug-responsive genes Sgk1 and Tsc22d3 resulted in alterations to dendritic spines in mice, possibly reflecting an altered potential for plastic changes.
Gene_expression (resulted) of Sgk1 in spines
3) Confidence 0.62 Published 2010 Journal Genome Biol. Section Body Doc Link 20459597 Disease Relevance 0 Pain Relevance 0
Significant interaction was detected for Sgk, Nfkbia, and Hspa1b, for example (Additional data file 1).
Gene_expression (detected) of Sgk
4) Confidence 0.59 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.60 Pain Relevance 0.55
On the other hand, transfection with the SGK shRNA (SGK1sh) mix did not cause pronounced changes in protrusion shape but resulted in a decrease in protrusion density compared to control neurons.
Gene_expression (transfection) of SGK1sh in neurons
5) Confidence 0.59 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.05 Pain Relevance 0
Double-immunofluorescence labeling with neuronal (NeuN) and astroglial (S100B) markers was used to identify cells that expressed SGK (Sgk1) and GILZ (Tsc22d3) proteins.
Gene_expression (expressed) of SGK in neuronal
6) Confidence 0.59 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.07 Pain Relevance 0.24
RU486 also altered the expression of several B1 genes, for example, Sgk1 and Plekhf1 (Figure 4g).
Gene_expression (expression) of Sgk1
7) Confidence 0.59 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.10
On the other hand, transfection with the SGK shRNA (SGK1sh) mix did not cause pronounced changes in protrusion shape but resulted in a decrease in protrusion density compared to control neurons.
Gene_expression (transfection) of SGK shRNA in neurons
8) Confidence 0.59 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.05 Pain Relevance 0
We demonstrated that knockdown of Sgk1 expression in neurons caused lower protrusion density and altered formation of dendritic spines [97].
Gene_expression (expression) of Sgk1 in spines
9) Confidence 0.59 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.24 Pain Relevance 0.18
Double-immunofluorescence labeling with neuronal (NeuN) and astroglial (S100B) markers was used to identify cells that expressed SGK (Sgk1) and GILZ (Tsc22d3) proteins.
Gene_expression (expressed) of Sgk1 in neuronal
10) Confidence 0.59 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.07 Pain Relevance 0.24
Furthermore, alterations in expression of Sgk and Nfkbia were also observed after acute administration of ethanol [43-45].
Gene_expression (expression) of Sgk
11) Confidence 0.53 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.21 Pain Relevance 0.75
Furthermore, we have identified a relatively large group of genes with parallel expression profiles to that of Tsc22d3 (Sgk, Klf15, Fzd2, Gpt2, Rhpn2, Nt5e, and Nfkbia), which may indicate morphine-induced co-regulation of these genes.
Gene_expression (expression) of Sgk associated with morphine
12) Confidence 0.53 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.12 Pain Relevance 0.51
Thus, treatment with a GC alone or combined with chemotherapy led to an increased protein expression of SGK-1 and MKP-1 while specific inhibition of these molecules by small interfering RNA reversed the anti-apoptotic effects of GC treatment in breast cancer cells [15].
Gene_expression (expression) of SGK-1 associated with breast cancer and apoptosis
13) Confidence 0.51 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.70 Pain Relevance 0.22
The membranes were then rinsed and incubated in the rabbit polyclonal antibodies MKP-1, BAG-1 (both from Santa Cruz, Heidelberg, Germany), SGK-1 (Stressgene, Victoria, Canada), X-IAP (New England Biolabs/Cell Signaling, Frankfurt, Germany) or in the mouse monoclonal antibodies: BCL-2 (Merck/Calbiochem, Darmstadt, Germany), ACTIN (clone C4, ICN, Aurora, Ohio, USA).
Gene_expression (rinsed) of SGK-1
14) Confidence 0.44 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.29 Pain Relevance 0.06
Since enhanced expression of MKP-1 and SGK-1 has been recently described to be involved in DEX-induced resistance in established breast cancer cell lines [15], we examined expression of these pro-survival molecules in pancreatic cancer cells by Western blot analysis together with expression of the anti-apoptotic molecules X-IAP and Bcl-2.
Gene_expression (expression) of SGK-1 associated with pancreatic cancer, breast cancer, apoptosis and dexamethasone
15) Confidence 0.39 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.70 Pain Relevance 0.21
During a time kinetic from 24 to 72 h, DEX strongly enhanced the levels of MKP-1, SGK1 and X-IAP, in several pancreatic cancer cell lines examined, while Bcl-2 expression was only marginally increased.
Gene_expression (levels) of SGK1 associated with pancreatic cancer and dexamethasone
16) Confidence 0.39 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.62 Pain Relevance 0.24
Therefore, enhanced expression of MKP-1, SGK-1, X-IAP and Bcl-2 but not of BAG-1 may be involved in DEX-induced therapy resistance of pancreatic carcinomas.


Gene_expression (expression) of SGK-1 associated with pancreatic cancer and dexamethasone
17) Confidence 0.39 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.84 Pain Relevance 0.24

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