INT168152

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.88
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ACAN) cell adhesion (ACAN) proteinaceous extracellular matrix (ACAN)
Anatomy Link Frequency
synovial fluid 1
T-cell 1
ACAN (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 57 99.32 Very High Very High Very High
Pain 6 98.16 Very High Very High Very High
cytokine 29 95.44 Very High Very High Very High
Arthritis 119 88.32 High High
Inflammation 16 85.84 High High
Osteoarthritis 22 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 1 93.08 High High
Juvenile Chronic Polyarthritis 90 88.32 High High
INFLAMMATION 13 85.84 High High
Arthritis 26 83.92 Quite High
Thrombotic Thrombocytopenic Purpura 4 17.72 Low Low
Disease 28 5.00 Very Low Very Low Very Low
Osteoarthritis 22 5.00 Very Low Very Low Very Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Experimental Arthritis 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Identification of a complex between fibronectin and aggrecan G3 domain in synovial fluid of patients with painful meniscal pathology.
aggrecan Binding (complex) of in synovial fluid associated with pain
1) Confidence 0.36 Published 2010 Journal Clin. Biochem. Section Title Doc Link 20460120 Disease Relevance 0.18 Pain Relevance 0.33
However, processing events removing the spacer region might generate a more promiscuous and destructive activity capable of disaggregating aggrecan–hyaluronan complexes through IGD proteolysis, resulting in the loss of aggrecan from the tissue.
aggrecan Spec (might) Binding (disaggregating) of
2) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.16 Pain Relevance 0.03
However, processing events removing the spacer region might generate a more promiscuous and destructive activity capable of disaggregating aggrecan–hyaluronan complexes through IGD proteolysis, resulting in the loss of aggrecan from the tissue.
aggrecan Binding (complexes) of
3) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.16 Pain Relevance 0.03
T-cell recognition of aggrecan, fibrillin, and MMP-3
aggrecan Binding (recognition) of in T-cell associated with metalloproteinase
4) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 0.38 Pain Relevance 0.34

General Comments

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