INT168188

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 9.00
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PLXNA2) intracellular (PLXNA2)
Anatomy Link Frequency
macula 4
eyes 1
fat 1
incus 1
muscle fiber 1
PLXNA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 113 100.00 Very High Very High Very High
Inflammation 35 100.00 Very High Very High Very High
Multiple sclerosis 35 99.92 Very High Very High Very High
Dopamine 1 99.16 Very High Very High Very High
Neuritis 50 98.44 Very High Very High Very High
Glutamate 9 89.84 High High
Pain matrix 2 89.44 High High
Migraine 5 88.24 High High
Neurotransmitter 6 84.72 Quite High
ketamine 10 44.16 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 100.00 Very High Very High Very High
Demyelinating Disease 38 99.92 Very High Very High Very High
Glaucoma 413 99.82 Very High Very High Very High
Disease 75 99.06 Very High Very High Very High
Optic Neuritis 50 98.44 Very High Very High Very High
Autoimmune Disease 44 96.40 Very High Very High Very High
Thrombosis 78 96.36 Very High Very High Very High
Infection 110 96.12 Very High Very High Very High
Ocular Hypertension 13 95.84 Very High Very High Very High
Injury 34 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This hypothesis derived from the results of the biochemical studies, mainly generated from our laboratory, on the possible metabolic shifts of tyrosine toward an activation of decarboxylase enzyme activity with an increased synthesis of traces amines, i.e. tyr, oct and syn, and an unphysiological synthesis of noradrenalin and dopamine.
Gene_expression (synthesis) of oct associated with dopamine
1) Confidence 0.58 Published 2010 Journal Neurol. Sci. Section Abstract Doc Link 20464574 Disease Relevance 0.49 Pain Relevance 0.75
Subsequently, OCT imaging of the right carotid artery was performed.
Gene_expression (imaging) of OCT in carotid artery associated with imagery
2) Confidence 0.52 Published 2008 Journal Heart Section Abstract Doc Link PMC2564841 Disease Relevance 1.18 Pain Relevance 0.09
The typical OCT image has a homoaxial resolution of 10 ?
Gene_expression (image) of OCT
3) Confidence 0.52 Published 2008 Journal Heart Section Body Doc Link PMC2564841 Disease Relevance 0.40 Pain Relevance 0.22
An OCT scan (Stratus OCT 3000, software version 4.0.1, Carl Zeiss Meditec Inc, Dublin, CA, USA) of the macula of the study eye was thereafter performed, in all 34 control subjects.
Gene_expression (scan) of OCT in macula
4) Confidence 0.29 Published 2010 Journal Graefes Arch Clin Exp Ophthalmol Section Body Doc Link PMC2877816 Disease Relevance 0.54 Pain Relevance 0
An OCT scan (Stratus OCT 3000, software version 4.0.1, Carl Zeiss Meditec Inc, Dublin, CA, USA) of the macula of the study eye was thereafter performed, in all 34 control subjects.
Gene_expression (performed) of OCT in macula
5) Confidence 0.29 Published 2010 Journal Graefes Arch Clin Exp Ophthalmol Section Body Doc Link PMC2877816 Disease Relevance 0.62 Pain Relevance 0
An OCT scan (Stratus OCT 3000, software version 4.0.1, Carl Zeiss Meditec Inc, Dublin, CA, USA) of the macula of the study eye was thereafter performed, in all 34 control subjects.
Gene_expression (scan) of OCT in macula
6) Confidence 0.29 Published 2010 Journal Graefes Arch Clin Exp Ophthalmol Section Body Doc Link PMC2877816 Disease Relevance 0.59 Pain Relevance 0
An OCT scan (Stratus OCT 3000, software version 4.0.1, Carl Zeiss Meditec Inc, Dublin, CA, USA) of the macula of the study eye was thereafter performed, in all 34 control subjects.
Gene_expression (performed) of OCT in macula
7) Confidence 0.29 Published 2010 Journal Graefes Arch Clin Exp Ophthalmol Section Body Doc Link PMC2877816 Disease Relevance 0.62 Pain Relevance 0
The aforementioned PPG studies used OCT-3 or GDx-VCC [2, 3, 9, 16].
Gene_expression (used) of OCT associated with glaucoma
8) Confidence 0.28 Published 2010 Journal The Open Ophthalmology Journal Section Body Doc Link PMC2928913 Disease Relevance 0.40 Pain Relevance 0.09
We furthermore investigated the influence of age at the time of OCT measurement, MS group (RRMS and SPMS with/without ON), and disease duration (change of RNFL per decade) in a mixed model for patient eyes including the three fold interaction term for sector, disease group and disease duration.
Gene_expression (measurement) of OCT in eyes associated with multiple sclerosis, disease and neuritis
9) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975633 Disease Relevance 1.50 Pain Relevance 0.94
Support for the theory of primary autoimmunity involving the eye muscles can be demonstrated by electron microscope examination in GO patients with relatively recent onset disease showing muscle fiber damage in the absence of OCT inflammation.14

Future directions

Gene_expression (directions) of OCT in muscle fiber associated with autoimmune disease, inflammation and disease
10) Confidence 0.19 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 1.10 Pain Relevance 0.18
The general consensus is that TAO is likely to reflect an autoimmune reaction during which sensitized T-cells and autoantibodies are directed against a thyroid and orbital tissue shared antigen such as the thyroid-stimulating hormone receptor (TSH-r) which is expressed in the thyroid, OCT and fat and, possibly, the extraocular muscle fiber (Box 1).9
Gene_expression (expressed) of OCT in fat
11) Confidence 0.17 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2874268 Disease Relevance 0.49 Pain Relevance 0
No high reflect light echogenic mass was detected by OCT.
Gene_expression (detected) of OCT
12) Confidence 0.08 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2267739 Disease Relevance 0.38 Pain Relevance 0
With ex vivo OCT imaging, all micro-structures of the middle ear such as the TM, malleus, incus, chodra tympani nerve, and tendon of the tensor tympani muscle can be readily identified.
Gene_expression (imaging) of OCT in malleus associated with imagery
13) Confidence 0.06 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018087 Disease Relevance 0 Pain Relevance 0.17
(c) Validation data from 2-D OCT image acquired ex vivo.
Gene_expression (image) of OCT
14) Confidence 0.06 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018087 Disease Relevance 0 Pain Relevance 0.04
(c) Validation data from 2-D OCT image acquired ex vivo.
Gene_expression (image) of OCT
15) Confidence 0.06 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018087 Disease Relevance 0.37 Pain Relevance 0.03
All of the TMs were dissected out for secondary ex vivo OCT imaging, and were subsequently fixed and embedded in paraffin for histological sectioning and comparative examination.

2.2 Instrumentation

Gene_expression (imaging) of OCT associated with imagery
16) Confidence 0.06 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018087 Disease Relevance 0.34 Pain Relevance 0.05
With ex vivo OCT imaging, all micro-structures of the middle ear such as the TM, malleus, incus, chodra tympani nerve, and tendon of the tensor tympani muscle can be readily identified.
Gene_expression (imaging) of OCT in incus associated with imagery
17) Confidence 0.02 Published 2010 Journal Biomedical Optics Express Section Body Doc Link PMC3018087 Disease Relevance 0 Pain Relevance 0.17

General Comments

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