INT1682

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Context Info
Confidence 0.37
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 7.38
Pain Relevance 8.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rem1) GTPase activity (Rem1) cellular_component (Rem1)
biological_process (Rem1)
Anatomy Link Frequency
muscle 1
finger 1
brainstem 1
CNA 1
neck muscle 1
Rem1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 6 100.00 Very High Very High Very High
tetrodotoxin 22 99.98 Very High Very High Very High
Morphine 25 99.48 Very High Very High Very High
sSRI 7 99.40 Very High Very High Very High
depression 39 99.28 Very High Very High Very High
amygdala 24 99.20 Very High Very High Very High
Pain 24 99.18 Very High Very High Very High
nociceptor 3 99.10 Very High Very High Very High
Endogenous opioid 3 98.00 Very High Very High Very High
Neuropeptide 6 97.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sleep Disorders 269 100.00 Very High Very High Very High
Hyperalgesia 12 100.00 Very High Very High Very High
Depression 51 99.28 Very High Very High Very High
Pain 32 99.18 Very High Very High Very High
Apnoea 5 98.72 Very High Very High Very High
Catalepsy 9 98.28 Very High Very High Very High
Congenital Anomalies 2 95.92 Very High Very High Very High
Airway Obstruction 1 93.60 High High
Urological Neuroanatomy 7 90.96 High High
Anxiety Disorder 85 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relative to the untreated controls and to their own pretreatment thresholds, the REM-deprived animals showed significantly reduced pain thresholds which were still evident 96 hours after the termination of the REM deprivation.
Negative_regulation (deprivation) of REM associated with pain
1) Confidence 0.37 Published 1979 Journal Percept Mot Skills Section Abstract Doc Link 225723 Disease Relevance 0.43 Pain Relevance 0.36
DESIGN: Two repeated-measures design protocols were conducted: (1) a sleep-loss protocol with 8 hours time-in-bed, 4 hours time-in-bed, and 0 hours time-in-bed conditions and (2) a REM sleep-loss protocol with 8 hours time-in-bed, 2 hours time-in-bed, REM deprivation, and non-REM yoked-control conditions.
Negative_regulation (deprivation) of non-REM
2) Confidence 0.37 Published 2006 Journal Sleep Section Body Doc Link 16494081 Disease Relevance 0.09 Pain Relevance 0
We report the first data showing, in healthy, pain-free, individuals, that modest reductions of sleep time and specific loss of rapid eye movement (REM) sleep produces hyperalgesia the following morning.
Negative_regulation (loss) of REM in eye associated with pain and hyperalgesia
3) Confidence 0.37 Published 2006 Journal Sleep Section Abstract Doc Link 16494081 Disease Relevance 0.46 Pain Relevance 0.38
RESULTS: Finger-withdrawal latency was shortened by 25% after 4 hours of time in bed the previous night relative to 8 hours of time in bed (p < .05), and REM sleep deprivation relative to a non-REM yoked-control sleep-interruption condition shortened finger-withdrawal latency by 32% (p < .02).
Negative_regulation (deprivation) of REM in finger
4) Confidence 0.37 Published 2006 Journal Sleep Section Body Doc Link 16494081 Disease Relevance 0.06 Pain Relevance 0
Sleep loss and REM sleep loss are hyperalgesic.
Negative_regulation (loss) of REM associated with hyperalgesia
5) Confidence 0.37 Published 2006 Journal Sleep Section Title Doc Link 16494081 Disease Relevance 0.38 Pain Relevance 0.37
DESIGN: Two repeated-measures design protocols were conducted: (1) a sleep-loss protocol with 8 hours time-in-bed, 4 hours time-in-bed, and 0 hours time-in-bed conditions and (2) a REM sleep-loss protocol with 8 hours time-in-bed, 2 hours time-in-bed, REM deprivation, and non-REM yoked-control conditions.
Negative_regulation (deprivation) of REM
6) Confidence 0.37 Published 2006 Journal Sleep Section Body Doc Link 16494081 Disease Relevance 0.09 Pain Relevance 0
CONCLUSION: These studies showed that the loss of 4 hours of sleep and specific REM sleep loss are hyperalgesic the following day.
Negative_regulation (loss) of REM
7) Confidence 0.37 Published 2006 Journal Sleep Section Body Doc Link 16494081 Disease Relevance 0.05 Pain Relevance 0
This suggests that REM suppression may not be necessary for improvement in narcolepsy.
Negative_regulation (suppression) of REM associated with sleep disorders
8) Confidence 0.37 Published 1985 Journal J Clin Psychiatry Section Abstract Doc Link 4066618 Disease Relevance 0.17 Pain Relevance 0.39
Using 30 Sprague-Dawley female rats, threshold to pain was measured over the course of recovery from REM sleep deprivation.
Negative_regulation (deprivation) of REM associated with pain and sleep disorders
9) Confidence 0.37 Published 1979 Journal Percept Mot Skills Section Abstract Doc Link 225723 Disease Relevance 0.44 Pain Relevance 0.34
Pain thresholds in rats during recovery from REM sleep deprivation.
Negative_regulation (deprivation) of REM associated with pain and sleep disorders
10) Confidence 0.37 Published 1979 Journal Percept Mot Skills Section Title Doc Link 225723 Disease Relevance 0.48 Pain Relevance 0.47
An examination was made of the effect of REM sleep deprivation (REMSD) on some forms of altered motor activity, such as akinesia and catalepsy, induced by intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) administration of morphine in adult, male Wistar rats.
Negative_regulation (deprivation) of REM associated with catalepsy, sleep disorders, intracerebroventricular and morphine
11) Confidence 0.37 Published 1986 Journal Sleep Section Abstract Doc Link 3020674 Disease Relevance 0.49 Pain Relevance 0.48
The proposed insufficiency of an endogenous opioid system might explain an increase in neuronal excitation during REMSD and the therapeutic effect of REM deficiency in some types of depression.
Negative_regulation (deficiency) of REM in neuronal associated with depression and endogenous opioid
12) Confidence 0.37 Published 1986 Journal Sleep Section Abstract Doc Link 3020674 Disease Relevance 0.48 Pain Relevance 0.93
REM sleep deprivation antagonizes morphine-induced akinesia and catalepsy.
Negative_regulation (deprivation) of REM associated with catalepsy, sleep disorders and morphine
13) Confidence 0.37 Published 1986 Journal Sleep Section Title Doc Link 3020674 Disease Relevance 0.55 Pain Relevance 0.83
In this way, SSRI treatment is associated with REM suppression, and this effect has been observed among normal controls as well as depressed patients (Sharpley and Cowen 1995; Vogel et al 1990; Pace-Schott et al 2001).
Negative_regulation (suppression) of REM associated with ssri
14) Confidence 0.34 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656315 Disease Relevance 0.16 Pain Relevance 0.62
This was due to a total suppression of REM and the consequent lack of REM apneas in two patients.
Negative_regulation (suppression) of REM associated with apnoea
15) Confidence 0.31 Published 1992 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 1736753 Disease Relevance 0.56 Pain Relevance 0.65
Arousal from REM sleep consisted of an increase in neck muscle EMG coinciding with a reduction of the typical REM 4-13 Hz power.
Negative_regulation (reduction) of REM in neck muscle
16) Confidence 0.23 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0 Pain Relevance 0
Of those individual features that were used to determine different sleep-wake stages, the overall hippocampal theta time (41% decrease) and single REM frequency (71% reduction during the REM sleep) were most affected.
Negative_regulation (reduction) of REM
17) Confidence 0.22 Published 1998 Journal Brain Res. Bull. Section Abstract Doc Link 9820735 Disease Relevance 0.26 Pain Relevance 0.03
Neurons containing the neuropeptide hypocretin (HCRT), also known as orexin are located in the lateral hypothalamus and hypothesized to inhibit REM sleep [1], [2].
Negative_regulation (inhibit) of REM in Neurons associated with neuropeptide
18) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.40 Pain Relevance 0.05
We reasoned that if the vlPAG neurons are important regulators of REM sleep and muscle tone then deletion of both the ligand and the target neurons in the vlPAG should have an additive effect on REM sleep and cataplexy. vlPAG lesion in the HCRT-ko mice increased REM sleep (+39% compared to HCRT-ko; +177% compared to WT), number of bouts of REM sleep, and further fragmented sleep architecture.
Negative_regulation (regulators) of REM in muscle associated with sleep disorders
19) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.40 Pain Relevance 0
Another area lateral to the vlPAG called the lateral pontine tegmentum (LPT) by one group [16] and the deep mesencephalic reticular nucleus (DPMe) by another [10] is also implicated in inhibiting REM sleep and cataplexy.
Negative_regulation (inhibiting) of REM in tegmentum associated with sleep disorders
20) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.31 Pain Relevance 0

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