INT168229

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
CeA 1
Oprm1 (Mus musculus)
Cea (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 11 100.00 Very High Very High Very High
Opioid 9 100.00 Very High Very High Very High
Morphine 2 100.00 Very High Very High Very High
opioid receptor 1 100.00 Very High Very High Very High
imagery 1 96.72 Very High Very High Very High
addiction 4 95.32 Very High Very High Very High
nMDA receptor 4 90.28 High High
Limbic system 1 73.92 Quite High
Glutamate receptor 1 73.24 Quite High
withdrawal 3 30.32 Quite Low
Disease Link Frequency Relevance Heat
Opiate Addiction 6 95.60 Very High Very High Very High
Nociception 1 39.52 Quite Low
Targeted Disruption 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To overcome these shortcomings, high-resolution imaging and molecular pharmacology were used to (1) Identify the ultrastructural localization of the essential NMDA-NR1 receptor (NR1) subunit and its relationship to the mu-opioid receptor (microOR), the major cellular target of abused opioids like morphine, in the CeA and (2) Determine the effect of CeA NR1 deletion on the physical, and particularly, psychological aspects of opioid dependence.
mu-opioid receptor Regulation (target) of CeA in CeA associated with addiction, opioid receptor, amygdala, opioid, imagery and morphine
1) Confidence 0.10 Published 2010 Journal Vitam. Horm. Section Abstract Doc Link 20472137 Disease Relevance 0.26 Pain Relevance 1.30

General Comments

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