INT168233

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.78
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col2a1) extracellular region (Col2a1) cytoplasm (Col2a1)
Anatomy Link Frequency
CII 2
IVD 2
Col2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 68 100.00 Very High Very High Very High
metalloproteinase 2 97.80 Very High Very High Very High
methotrexate 41 97.12 Very High Very High Very High
Inflammation 20 95.44 Very High Very High Very High
rheumatoid arthritis 17 88.48 High High
imagery 13 85.52 High High
Pain 1 85.52 High High
Chronic low back pain 1 73.04 Quite High
spinal inflammation 1 30.40 Quite Low
cytokine 13 24.80 Low Low
Disease Link Frequency Relevance Heat
Arthritis 70 100.00 Very High Very High Very High
INFLAMMATION 19 95.44 Very High Very High Very High
Disease 14 94.64 High High
Autoimmune Disease 4 90.84 High High
Rheumatoid Arthritis 17 88.48 High High
Neck Pain 1 85.52 High High
Hypercalcemia 2 77.80 Quite High
Osteoporosis 2 77.16 Quite High
Injury 1 76.48 Quite High
Intervertebral Disk Degeneration 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II-collagen level, decreased type X-collagen protein level, and increased Col2alpha1 mRNA expression at all time points; and decreased Col10alpha1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1beta mRNA expression induced by upright posture for 7 and 9 months.
Positive_regulation (increased) of Transcription (expression) of Col2alpha1 in IVD associated with metalloproteinase
1) Confidence 0.45 Published 2010 Journal J. Pharmacol. Sci. Section Abstract Doc Link 20472983 Disease Relevance 0.23 Pain Relevance 0.21
CIA: collagen-induced arthritis; CII: type II collagen; CT: computed tomography; ?
Positive_regulation (induced) of Transcription (arthritis) of type II collagen in CII associated with arthritis
2) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 1.54 Pain Relevance 0.78

General Comments

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