INT168245

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.63
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tp53) mitochondrion (Tp53) aging (Tp53)
endoplasmic reticulum (Tp53) enzyme binding (Tp53) protein complex assembly (Tp53)
Anatomy Link Frequency
joint 4
Tp53 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 2 94.80 High High
Arthritis 118 94.36 High High
rheumatoid arthritis 32 84.24 Quite High
Inflammation 16 65.28 Quite High
fibrosis 2 55.12 Quite High
Crohn's disease 2 47.28 Quite Low
Chronic pancreatitis 2 45.52 Quite Low
corticosteroid 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 38 96.76 Very High Very High Very High
Arthritis 40 94.36 High High
Experimental Arthritis 78 89.44 High High
Rheumatoid Arthritis 32 84.24 Quite High
Apoptosis 99 80.28 Quite High
INFLAMMATION 18 65.28 Quite High
Stress 2 63.64 Quite High
Death 5 61.04 Quite High
Atherosclerotic Plaque 2 59.52 Quite High
Pulmonary Fibrosis 2 55.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcription of p53 is probably

increased in response to the toxic environment of the inflamed joint.

Positive_regulation (increased) of Transcription (Transcription) of p53 in joint
1) Confidence 0.70 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17810 Disease Relevance 1.31 Pain Relevance 0.35
Transcription of p53 is

probably increased in response to the toxic environment of the inflamed joint, with local production of oxygen radicals, nitric oxide [30], and cytokines.

Positive_regulation (increased) of Transcription (Transcription) of p53 in joint associated with cytokine
2) Confidence 0.47 Published 2000 Journal Arthritis Res Section Body Doc Link PMC17810 Disease Relevance 1.32 Pain Relevance 0.40
CONCLUSION: Our preliminary data show that N2O induced a selective increase in nNOS and p53 transcription.
Positive_regulation (increase) of Transcription (transcription) of p53
3) Confidence 0.36 Published 2010 Journal Minerva Anestesiol Section Body Doc Link 20473255 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox